| Record no | GENE NAME | SNP ID | CHANGES | ANCESTRAL ALLELES | FUNCTIONAL CONSEQUENCES | DISEASE | POPULATION | Pubmed ID | Comments |
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| 1 | NLRP4 | rs16986718 | G/A | A | Synonymous Variant | Asthma | Korean descent of population | 30526007 | The minor allele of rs16986718 G>A in NLRP4 was significantly associated with frequent acute exacerbation through an interaction with smoking status in adult asthmatics. The minor (A) allele of rs16986718 may be a risk factor for the occurrence of acute exacerbation in smokers. |
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| 2 | NLRP1 | rs11651270 | C/T | C | Missense Variant | Paediatric Asthma | Brazilian population | 29154202 | NLRP1 variant rs11651270 was significantly associated to asthma in trios (TDT) analysis. rs11651270 was also associated with asthma severity and total IgE level in asthmatic children. |
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| 3 | NLRP1 | rs12150220 | A/T | A | Missense Variant | Paediatric Asthma | Brazilian population | 29154202 | NLRP1 variant rs12150220 was significantly associated to asthma in trios (TDT) analysis. |
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| 4 | NLRP1 | rs2670660 | A/G | A | - | Paediatric Asthma | Brazilian population | 29154202 | NLRP1 variant rs2670660 was significantly associated to asthma in trios (TDT) analysis. rs2670660 was also associated with asthma severity and total IgE level in asthmatic children. |
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| 5 | NR3C1 | rs41423247 | C/G | G | Intron Variant | Bronchial Asthma | - | 30480407 | Comparison of genotype frequency for BclI polymorphism in glucocorticoid receptor gene in individuals with different ratio of fat centralization in the control group and in the patients with Bronchial Asthma separately showed statistically significant differences in the distribution of gene allelic variations only among the patients with Bronchial Asthma. The G/G genotype in the patients with visceral obesity was associated with Bronchial Asthma. |
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| 6 | NOD2 | rs5743266 | A/G/T (FWD) | G | Intron Variant | Asthma | European Ancestry | 27130862 | rs5743266 was one of the top SNPs in genome-wide associated regions from the meta-analysis of Time to Asthma Onset (TAO). |
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| 7 | NOD2, CYLD | rs7205760 | A/C/G | C | - | Asthma | European Ancestry | 27130862 | rs7205760 was one of the top SNPs in genome-wide associated regions from the meta-analysis of Time to Asthma Onset (TAO). |
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| 8 | NPSR1 | rs324981 | A/T | T | Missense Variant | Asthma | Han Chinese population | 27176146 | The majority of patients with asthma had the T+ allele in the NPSR1 gene. |
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| 9 | NOD2 | rs3135499 | A/C | C | Non Coding Transcript Variant | Childhood Asthma | Chinese Han population | 30950247 | The rs3135499 C allele was associated with a significantly increased risk of asthma as compared with the rs3135499 A allele. The rs3135499 polymorphism of NOD2 gene may play a role in the pathogenesis of asthma. |
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| 10 | NOD1 | rs2075820 | A/G (REV) | G | Missense Variant | Childhood Asthma | Tunisian population | 30874883 | The NOD1 rs2075820 variant was associated with a higher childhood asthma risk. |
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| 11 | NR3C1 | rs41423247 | C/G | G | Intron Variant | Asthma | - | 29729712 | The BclI polymorphism of NR3C1 was significantly associated with asthma in adults. |
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| 12 | NPSR1 | rs887020 | A/G | A | 5 Prime UTR Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs887020 with RORA SNP rs2899662 affect the risk for asthma. RORA* NPSR1 interactions appear to be involved in mechanisms specific for nocturnal asthma. |
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| 13 | NPSR1 | rs963218 | C/T (REV) | T | Intron Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs963218 with RORA SNPs rs2899662, rs12591848, rs4775289, rs7171681 affect the risk for asthma. RORA* NPSR1 interactions appear to be involved in mechanisms specific for nocturnal asthma. |
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| 14 | NPSR1 | rs324396 | C/T | T | Intron Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs324396 with RORA SNP rs4775301, rs7171681, rs341382 affect the risk for asthma. RORA* NPSR1 interactions appear to be involved in mechanisms specific for nocturnal asthma. |
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| 15 | NPSR1 | rs714588 | A/G | G | Intron Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs714588 with RORA SNPs rs8042149, rs4775301 affect the risk for asthma. RORA* NPSR1 interactions appear to be involved in mechanisms specific for nocturnal asthma. |
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| 16 | NPSR1 | rs2530547 | C/T | T | 5 Prime UTR Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs2530547 with RORA SNP rs12591848 affect the risk for asthma. RORA* NPSR1 interactions appear to be involved in mechanisms specific for nocturnal asthma. |
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| 17 | NPSR1 | rs727162 | A/C/G (REV) | G | Missense Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs727162 with RORA SNP rs11071561 affect the risk for asthma. RORA* NPSR1 interactions appear to be involved in mechanisms specific for nocturnal asthma. |
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| 18 | NPSR1 | rs740347 | A/C/G/T | G | Intron Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs740347 with RORA SNP rs4775289 affect nocturnal asthma symptoms. |
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| 19 | NPSR1 | rs324981 | A/T | T | Missense Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs324981 with RORA SNP rs11071561 affect nocturnal asthma symptoms. |
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| 20 | NPSR1 | rs1379928 | C/T (REV) | C | Intron Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs1379928 with RORA SNPs rs4775292, rs1243790, rs17204454 affect nocturnal asthma symptoms. |
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| 21 | NPSR1 | rs324384 | C/T | T | Intron Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs324384 with RORA SNP rs2899662 affect nocturnal asthma symptoms. |
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| 22 | NPSR1 | rs324957 | A/G | G | Intron Variant | Nocturnal Asthma | - | 30927345 | Interaction of NPSR1 SNP rs324957 with RORA SNP rs2899662 affect nocturnal asthma symptoms. |
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| 23 | NRP2 | rs849558 | A/C/G (REV) | A | Intron Variant | Asthma and Allergy Traits | Saguenay Lac Saint Jean Population | 30206357 | rs849558 was found to be associated with serum IgE levels. |
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| 24 | NPY | rs5574 | C/T | T | Synonymous Variant | Asthma | South-east Asian population | 27469060 | The CT genotype of rs5574 is significantly associated with prevalent asthma. |
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| 25 | NPY | rs17149106 | G/T | G | 2KB Upstream Variant | Asthma | South-east Asian population | 27469060 | The GT genotype of rs17149106 is significantly associated with prevalent asthma. |
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| 26 | NPSR1 | rs887020 | A/G | A | 5 Prime UTR Variant | Childhood Asthma | Swedish population | 28463995 | rs887020 showed significant association with asthma. |
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| 27 | NPSR1 | rs2531840 | A/G | A | Intron Variant | Childhood Asthma | Swedish population | 28463995 | rs2531840 showed significant association with asthma. |
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| 28 | NPSR1 | rs11770777 | A/C/G | G | Intron Variant | Childhood Asthma | Swedish population | 28463995 | rs11770777 showed significant association with asthma. |
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| 29 | NPS | rs1931704 | A/G | G | - | Childhood Asthma | Swedish population | 28463995 | NPS SNP (rs1931704) in strong linkage disequilibrium with rs4751440 was significantly associated with physician-diagnosed childhood asthma at age 8 years under dominant and additive models. |
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| 30 | NPS | rs4751440 | A/C/G | G | Missense Variant | Childhood Asthma | Swedish population | 28463995 | The allele C in NPS rs4751440 encoding for Leu(6) is protective for asthma. |
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| 31 | NR3C1 | rs6195 | A/T | T | 3 Prime UTR Variant | Asthma | - | 27081784 | A correlation between the N363S SNP (rs6195) of the NR3C1 gene and IL15 mRNA expression was demonstrated in asthmatics. |
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| 32 | NAF1 | rs4132177 | A/C | C | - | Asthma | Dutch population | 27439200 | The minor allele A of rs4132177 on chromosome 4 near NAF1 was associated with a lower risk of atopy within asthmatics. |
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| 33 | NFKB1 | rs28450894 | C/G/T | C | Intron Variant | Childhood Asthma | Puerto Rican population, Mexican population, African American population | 29509491 | The T allele of rs28450894 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. The low BDR associated T allele of NFKB1 (rs28450894) is found predominantly among African populations. The low BDR associated T allele of rs28450894 is significantly associated with decreased expression of SLC39A8 in blood. |
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| 34 | NFKB1 | rs4648006 | C/T | C | Intron Variant | Childhood Asthma | Puerto Rican population, Mexican population, African American population | 29509491 | The T allele of rs4648006 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. |
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| 35 | NRROS | rs4916533 | C/T | C | Intron Variant | Asthma, Allergic Diseases | European population | 29785011 | rs4916533 was associated with asthma and allergic diseases. |
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| 36 | NR1D1 | rs2102928 | C/T | C | Intron Variant | Asthma | - | 27554816 | rs2102928 is an eQTL for TOP2A gene which is significantly associated with asthma risk. |
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| 37 | NEU1 | rs9267901 | C/T | C | - | Asthma | - | 27554816 | rs9267901 is an eQTL for NEU1 gene which is significantly associated with asthma risk. |
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| 38 | NFIA | rs12122228 | A/G/T | G | Non Coding Transcript Variant | Asthma plus Allergic Rhinitis | French population | 24560411 | The single nucleotide polymorphism (rs12122228) specifically associated to asthma plus rhinitis is located in the flanking 5' untranslated region of the nuclear factor I/A (NFIA) gene, a strong candidate gene for asthma and AR. |
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