Browse Result

Total number of records for in O of in DAAB (Version-2) database: 15

Record no	GENE NAME	SNP ID	CHANGES	ANCESTRAL ALLELES	FUNCTIONAL CONSEQUENCES	DISEASE	POPULATION	Pubmed ID	Comments
1	ORMDL3	rs11650680	C/T	C	-	Asthma	Pakistani population	29588858	In rs11650680 of ORMDL3 gene the CT genotype is more prevalent in female asthma cases in comparison with female controls.
2	ORMDL3	rs8076131	A/C/G	A	Intron Variant	Allergic Asthma	Chinese population	26483175	The 17q12-21 locus has a strong genetic association with Allergic Asthma but not with Allergic Rhinitis. The polymorphic effect of this locus is attributed to the linkage set tagged by rs8076131, which affects the expression of ORMDL3, PPP1R1B, ZPBP2 and GSDMB and is correlated with high IgE levels and eosinophil counts in subjects bearing the risk genotype.
3	ORMDL3	rs8076131	A/C/G	A	Intron Variant	Asthma	American Indian population	28668238	rs8076131 was suggestive of case control status considering the major allele in a dominant model. This SNP was associated with asthma.
4	OXA1L	rs4981436	C/T	T	Intron Variant	Asthma, Atopy	South American population	30032071	Significant association between C allele of OXA1L SNP rs4981436 and asthma was noted in South American population.
5	OXA1L	rs17619	A/G	G	Missense Variant	Asthma, Atopy	South American population	30032071	Significant association between A allele of OXA1L SNP rs17619 and production of IFNG stimulated with Blomia tropicalis was noted in South American population.
6	OXA1L	rs8572	A/G (REV)	G	Missense Variant	Asthma, Atopy	South American population	30032071	Significant association between G allele of OXA1L SNP rs8572 with positive skin prick test for dog epithelium, Periplanata americana, Dermatophagoides pteronyssinus and specific IgE for Dermatophagoides pteronyssinus was noted in South American population.
7	ORMDL3	rs12603332	C/T	T	Intron Variant	Male Asthma	Pakistani population	28055272	The risk allele (C allele) for rs12603332 was found to be significantly associated with male asthma patients residing in urban localities of Lahore.
8	ORMDL3	rs4065275	A/G/T	A	Intron Variant	Asthma	-	27848966	The asthma-risk variants rs4065275 and rs12936231 switched CTCF-binding sites in the 17q21 locus and 4C-Seq assays showed that several distal cis-regulatory elements upstream of the disrupted ZPBP2 CTCF-binding site interacted with the ORMDL3 promoter region in CD4+ T cells exclusively from subjects carrying asthma-risk alleles.
9	ORMDL3	rs12603332	C/T	T	Intron Variant	FEV1, FVC	Greenlandic population	28740106	The homozygous CC genotype of rs12603332 in ORMDL3 was associated with higher values of FEV1 and FVC than the homozygous CT genotype in Greenlandic population.
10	ORMDL3	rs4065275	A/G/T	A	Intron Variant	FEV1, FVC	Greenlandic population	28740106	The GG genotype of rs4065275 in ORMDL3 was associated with higher values of FEV1 and FVC than the GA genotype in Greenlandic Inuit.
11	ORMDL3	rs4795405	A/C/T	T	Intron Variant	Asthma	Dutch population	27439200	rs4795405 was significantly associated with asthma.
12	ORMDL3	rs7216389	C/T	T	Intron Variant	Asthma	-	26064206	rs7216389 was significantly associated with increased asthma risk in overall population. Children with variant T allele (TT or TC) and adults with TT homozygote in rs7216389 are at high risks to suffer from asthma.
13	ORMDL3	rs11650680	C/T	C	-	Asthma	-	26064206	People with T allele in rs11650680 are protected from asthma.
14	ORMDL3	rs12603332	C/T	T	Intron Variant	Asthma	-	26064206	People with T allele in rs12603332 are protected from asthma.
15	ORMDL3	rs7216389	C/T	T	Intron Variant	Childhood Asthma	Chinese population	23096927	The ORMDL3 gene influences childhood asthma and the TT genotype of the rs7216389 polymorphism is associated with childhood asthma in the Chinese population.