| Record no | GENE NAME | SNP ID | CHANGES | ANCESTRAL ALLELES | FUNCTIONAL CONSEQUENCES | DISEASE | POPULATION | Pubmed ID | Comments |
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| 1 | PTGS1 | rs5788 | A/C | C | Synonymous Variant | Diisocyanate induced Asthma (DA) | Caucasian French Canadians | 25721048 | In a dominant model, the PTGS1 rs5788 SNP was associated with a protection against Diisocyanate induced Asthma (DA). |
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| 2 | PTGS2 | rs20417 | A/C/G | A | 2KB Upstream Variant | Diisocyanate induced Asthma (DA) | Caucasian French Canadians | 25721048 | The frequency of the PTGS2 rs20417 SNP showed only a marginal significance between the Diisocyanate induced Asthma (DA) group and asymptomatic diisocyanate exposed controls in the univariate analysis. PTGS2 rs20417 SNP showed an association with an increased risk of Diisocyanate induced Asthma (DA) in a recessive model. |
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| 3 | PPAR | rs1805192 | C/G | C | Missense Variant | Childhood Bronchial Asthma | Chinese Han ethnicity | 28590769 | Significant associations was found between rs1805192 of PPAR and susceptibility to and prognosis of childhood bronchial asthma, providing novel target for treating the disorder. The haplotype analysis suggested that CC of PPAR rs1805192 was correlated with levels of VD, IL-4, and IL-5. |
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| 4 | PPAR | rs10865710 | C/G | G | Intron Variant | Childhood Bronchial Asthma | Chinese Han ethnicity | 28590769 | Significant associations was found between rs10865710 of PPAR and susceptibility to and prognosis of childhood bronchial asthma, providing novel target for treating the disorder. The haplotype analysis suggested that CC of PPAR rs10865710 was correlated with levels of VD, IL-4, and IL-5. |
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| 5 | PTCHD3 | rs660498 | A/G | A | - | Childhood Asthma | European population, African American population | 27142222 | A novel variant in the PTCHD3 gene was significantly associated with asthma (rs660498) independent of obesity status. |
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| 6 | PSMD3 | rs8066582 | C/T | C | Intron Variant | Asthma | Slovenian population | 27163155 | rs8066582 was associated with childhood asthma. |
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| 7 | PSMD3 | rs9916279 | C/T | T | Synonymous Variant | Asthma | Slovenian population | 27163155 | rs9916279 was associated with asthma in smokers. |
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| 8 | PLA2G4 | rs932476 | A/G | A | Intron Variant | Childhood Bronchial Asthma | - | 30782278 | PLA2G4 rs932476 polymorphism may has certain influence on children's response to the leukotriene receptor antagonist montelukast, possibly by affecting the level of leukotriene B4 (LTB4). |
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| 9 | PBX2 | rs204993 | C/T (REV) | C | Intron Variant | Allergic Rhinitis, Asthma | Han Chinese population | 26852910 | The C allele of rs204993 in the PBX2 gene from the 6p21.3 locus was significantly associated with Allergic Rhinitis. The PBX2 gene in the 6p21.3 asthma susceptibility locus may be associated with increased risk for both Allergic Rhinitis and asthma in Chinese subjects. |
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| 10 | PDCD1 | rs11568821 | A/C/G (REV) | G | Intron Variant | Allergic Asthma | Russian (Caucasian) population, Buryat (Asian) population | 27286421 | A significant association of the PD-1.3 (rs11568821) polymorphism with IgE-mediated bronchial asthma and total serum IgE level in the Russian population was observed. Combined genotype AA+AG was correlated with risk of developing allergic bronchial asthma and lower concentrations of total serum IgE compared with the wild-type genotype GG. PD-1.3 polymorphism of the PD-1 gene (PDCD1) may contribute to the development of allergic asthma in the Russians but not in the Buryats. |
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| 11 | PTTG1IP | rs1344110 | A/G (REV) | A | Intron Variant | Asthma | Dutch population | 27709636 | Minor allele of rs1344110 was associated with less severe BHR and higher lung tissue gene expression. PTTG1IP was associated with BHR severity in adult asthma. |
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| 12 | PTPN22 | rs1310182 | C/G/T (REV) | T | Intron Variant | Allergic Rhinitis with Asthma (In Children) | Chinese Han population | 27917628 | For PTPN22, an increased prevalence of the CC genotype and C allele in rs1310182 were identified in Allergic Rhinitis group. |
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| 13 | PLAUR | rs4803648 | A/T | A | 3 Prime UTR variant | Asthma | - | 26869673 | rs4803648 was associated with Airway hyperresponsiveness, Basal Epithelial Proliferation and Collagen deposition in asthmatics. |
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| 14 | PLAUR | rs4802189 | A/C | A | 3 Prime UTR variant | Asthma | - | 26869673 | rs4802189 was associated with Airway hyperresponsiveness, Basal Epithelial Proliferation and Basement memebrane thickness in asthmatics. |
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| 15 | PLAUR | rs4251938 | A/G (REV) | A | Intron Variant | Asthma | - | 26869673 | rs4251938 was associated with Basal Epithelial Proliferation and Basement memebrane thickness in asthmatics. |
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| 16 | PLAUR | rs2302524 | C/T | T | Missense Variant | Asthma | - | 26869673 | rs2302524 was associated with Basal Epithelial Proliferation in asthmatics. |
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| 17 | PLAUR | rs4251864 | C/T (REV) | T | Intron Variant | Asthma | - | 26869673 | rs4251864 was associated with Airway hyperresponsiveness in asthmatics. |
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| 18 | PLAUR | rs4251831 | C/G/T (REV) | G | Intron Variant | Asthma | - | 26869673 | rs4251831 was associated with Basal Epithelial Proliferation in asthmatics. |
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| 19 | PLAUR | rs2356338 | G/T | G | 2KB Upstream Variant | Asthma | - | 26869673 | rs2356338 was associated with Basal Epithelial Proliferation in asthmatics. |
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| 20 | PLAUR | rs344779 | G/T | T | - | Asthma | - | 26869673 | rs344779 was associated with Basal Epithelial Proliferation in asthmatics. |
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| 21 | PLAUR | rs4493171 | C/T | C | - | Asthma | - | 26869673 | rs4493171 was associated with Collagen deposition in asthmatics. |
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| 22 | PLAUR | rs1994417 | C/T | C | - | Asthma | - | 26869673 | rs1994417 was associated with Collagen deposition in asthmatics. |
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| 23 | PLAUR | rs346043 | C/T | T | - | Asthma | - | 26869673 | rs346043 was associated with Basal Epithelial Proliferation in asthmatics. |
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| 24 | PAI-1 | rs2227631 | A/G | A | 2KB Upstream Variant | Asthma | Latino population | 27556405 | The PAI-1 SNP rs2227631 itself does not increase the odds of developing asthma. This genetic variant of PAI-1 (rs2227631) together with early life Lower Respiratory Infection (LRI) such as RSV bronchiolitis is associated with an increased risk of asthma, morbidity, and reduced lung function in Latino population. |
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| 25 | PLA2G4A | rs932476 | A/G | A | Intron Variant | Adult onset Asthma | European population | 27504716 | rs932476 in PLA2G4A was marginally associated with asthma. The risk of current adult-onset asthma was decreased among low molecular weight agents and irritants exposed participants for G carriers of rs932476 in PLA2G4A. |
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| 26 | PLA2R1 | rs2667026 | C/T (REV) | C | - | Adult onset Asthma | European population | 27504716 | The risk of current asthma was increased among low molecular weight agents and irritants exposed participants for G carriers of rs2667026 near PLA2R1, whereas inverse and significant effects were observed among unexposed participants. |
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| 27 | PRKD1 | rs1958980 | C/T (REV) | T | Intron Variant | Adult onset Asthma | European population | 27504716 | The risk of current adult-onset asthma was decreased among low molecular weight agents and irritants exposed participants for G carriers of rs1958980 in PRKD1. |
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| 28 | PRKD1 | rs1958987 | A/G (REV) | A | Intron Variant | Adult onset Asthma | European population | 27504716 | The risk of current adult-onset asthma was decreased among low molecular weight agents and irritants exposed participants for T carriers of rs1958987 in PRKD1. |
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| 29 | PRKD1 | rs11847351 | A/C/G | A | Intron Variant | Adult onset Asthma | European population | 27504716 | The risk of current adult-onset asthma was decreased among low molecular weight agents and irritants exposed participants for G carriers of rs11847351 in PRKD1. |
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| 30 | PRKCA | rs6504453 | C/T | T | Intron Variant | Adult onset Asthma | European population | 27504716 | The risk of current asthma was decreased significantly for T carriers of rs6504453 in PRKCA in Low Molecular Weight Agents and Irritants exposed participants, whereas inverse and significant effects were observed among unexposed participants. The T allele at rs6504453 in PRKCA was associated with increased gene expression in lung tissue. |
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| 31 | PAI-1 | - | - | - | Promoter Polymorphism | Asthma with Allergic Rhinitis | Croatian population | 28258374 | Genotype PAI-1 4G/4G is significantly more common in asthma patients with allergic rhinitis compared to the genotype 5G/5G. Carriers of the genotype 4G/5G also have a borderline statistical significance. The carriers of at least one 4G allele are at a higher risk for developing symptoms of allergic rhinitis in asthma. Polymorphism 4G/5G of PAI-1 serves as a risk factor for the development of allergic rhinitis symptoms in patients With Asthma. |
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| 32 | PRKG1 | rs7903366 | C/T | T | Intron Variant | Asthma | African American population | 30206298 | rs7903366 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. |
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| 33 | PRKG1 | rs7070958 | A/G | A | Intron Variant | Asthma | African American population | 30206298 | rs7070958 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. |
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| 34 | PRKG1 | rs7081864 | A/G | A | Intron Variant | Asthma | African American population | 30206298 | rs7081864 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. |
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| 35 | PDE4D | rs1588265 | A/G/T | A | Intron Variant | Asthma | Dutch population | 27439200 | The risk allele A of rs1588265 was significantly associated with asthma. |
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| 36 | PLCB1 | rs16995064 | C/G | C | Intron Variant | Childhood Asthma | Puerto Rican population, Mexican population, African American population | 29509491 | The G allele of rs16995064 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. |
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| 37 | PGAP3 | rs14050 | A/G (REV) | G | Non Coding Transcript Variant | Asthma | - | 27554816 | rs14050 is an eQTL for GRB7 gene which is significantly associated with asthma risk. |
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| 38 | PGAP3 | rs2941503 | A/G | G | Non Coding Transcript Variant | Asthma | - | 27554816 | rs2941503 is an eQTL for CISD3 gene which is significantly associated with asthma risk. |
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| 39 | PGAP3 | rs903502 | A/C/G (REV) | G | Intron Variant | Asthma | - | 27554816 | rs903502 is an eQTL for PGAP3 gene which is significantly associated with asthma risk. |
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| 40 | PGAP3 | rs2941503 | A/G | G | Non Coding Transcript Variant | Asthma | - | 27554816 | rs2941503 is an eQTL for STARD3 gene which is significantly associated with asthma risk. |
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| 41 | P2RY12 | rs17282940 | C/G/T | C | Intron Variant | Asthma | - | 27554816 | rs17282940 is an eQTL for P2RY12 gene which is significantly associated with asthma risk. |
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| 42 | PGAP3 | rs12150298 | C/T | C | Intron Variant | Asthma | - | 27554816 | rs12150298 is an eQTL for NR1D1 gene which is significantly associated with asthma risk. |
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| 43 | PTCSC3 | rs7148603 | A/G | A | - | Asthma | - | 27554816 | rs7148603 is an eQTL for PTCSC3 gene which is significantly associated with asthma risk. |
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| 44 | PDPN | rs355022 | C/T | T | 2KB Upstream Variant | Atopic Dermatitis | Korean population | 26082584 | The rs355022 SNP and the C-A haplotype in the PDPN gene were significantly associated with intrinsic Atopic Dermatitits. |
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| 45 | PDPN | rs425187 | A/G | A | Intron Variant | Atopic Dermatitis | Korean population | 26082584 | The rs425187 SNP and the C-A haplotype in the PDPN gene were significantly associated with intrinsic Atopic Dermatitits. |
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