| Record no | GENE NAME | SNP ID | CHANGES | ANCESTRAL ALLELES | FUNCTIONAL CONSEQUENCES | DISEASE | POPULATION | Pubmed ID | Comments |
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| 1 | STIP1 | rs2236647 | C/T | T | Intron variant | Asthma | Arab ethnicity | 29749828 | Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma. The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls. The rs2236647 SNP could act as a reliable tool to identify individuals at risk of developing asthma and provision of early intervention in population of Arab descent. |
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| 2 | STAT4 | rs16833215 | A/G | A | Intron Variant | Viral Respiratory Illness, Asthma | European or American European | 26399222 | In the STAT4 gene, an intronic SNP, rs16833215, was found to be associated with the number of illnesses in RhinoGen study and with wheezing or asthma phenotypes in COAST (Childhood Origins of Asthma birth cohort study). |
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| 3 | STAT4 | rs4853546 | A/G | G | Intron Variant | Viral Respiratory Illness, Asthma | European or American European | 26399222 | Intronic SNP in STAT4, rs4853546, was significantly associated with asthma in RhinoGen study, asthma exacerbations in COPSAC (Copenhagen Prospective Study on Asthma in Childhood) study, and RSV wheezing illnesses in COAST (the Childhood Origins of Asthma) study. |
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| 4 | STAT4 | rs1031509 | T/G | G | Intron Variant | Childhood Asthma | Czech Republican population | 28807506 | TG + GG genotypes on rs1031509 near STAT4 was associated with 5-times greater odds of asthma diagnosis at the highest Benzo[a]Pyrene range, compared to the odds at the reference range. |
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| 5 | sRAGE | rs2070600 | T/C | C | Missense Variant | Neutrophilic Asthma | Chinese population | 29257350 | The frequency of G82S genotypes was significantly different between neutrophilic and non-neutrophilic asthmatics. Neutrophilic asthmatics with genotypes A/G or A/A had significantly decreased sRAGE levels compared with the G/G genotype. Those with the A/G and A/A genotype displayed a trend toward lower FEV1% Pre compared with those with the G/G genotype. |
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| 6 | SOCS5 | rs6737848 | C/G | C | Intron Variant | Allergic Bronchial Asthma | Russian population | 31094455 | Homozygous genotype of СС gene of SOCS5 rs6737848 is a risk factor for allergic bronchial asthma. |
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| 7 | SOD2 | rs5746136 | C/T | C | Intron Variant | Childhood Asthma | Asian population | 29411558 | SOD2 TT genotype was associated with higher risk of asthma compared with the CC genotype. |
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| 8 | SPATS2L | rs295137 | A/G (REV) | G | - | Moderate-To-Severe Asthma Exacerbations (In Children) | Caucasian population | 30644648 | rs295137 in SPATS2L was significantly associated with increased odds of Emergency department management failure in case of moderate to severe ssthma exacerbations in children. |
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| 9 | STAT6 | rs4559 | A/G (REV) | G | Non Coding Transcript Variant | Non Atopic Asthma | Pakistani population | 30511616 | rs4559 SNP in STAT6 was found to be associated with non-atopic asthma risk. |
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| 10 | STAT6 | rs324011 | C/T | C | Intron Variant | Non Atopic Asthma | Pakistani population | 30511616 | rs324011 SNP in STAT6 was found to be associated with non-atopic asthma risk. |
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| 11 | ST2 | rs1041973 | A/C | A | Missense Variant | Allergic Conjunctivitis, Asthma | - | 29787780 | The minor allele of ST2 SNP rs1041973 associated with allergic conjunctivitis. The minor allele of rs1041973 echibits an inverse association with eosinophilia. ST2 SNP rs1041973 exhibited an inverse relationship with asthma. |
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| 12 | ST2 | rs10192036 | A/C | C | Missense Variant | Asthma | - | 29787780 | ST2 SNP rs10192036 exhibited an inverse relationship with asthma. |
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| 13 | ST2 | rs4988956 | A/G | G | Missense Variant | Asthma | - | 29787780 | ST2 SNP rs4988956 exhibited an inverse relationship with asthma. |
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| 14 | ST2 | rs10192157 | C/T | C | Missense Variant | Asthma | - | 29787780 | ST2 SNPrs10192157 exhibited an inverse relationship with asthma. |
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| 15 | ST2 | rs10206753 | C/G/T | T | Missense Variant | Asthma | - | 29787780 | ST2 SNPrs10206753 exhibited an inverse relationship with asthma. |
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| 16 | ST2 | rs1420101 | A/G (REV) | A | Non Coding Transcript Variant | Asthma | - | 29787780 | ST2 SNPrs1420101 was associated with asthma. |
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| 17 | STAT4 | rs925847 | C/T | C | Intron Variant | Bronchial Asthma | Japanese population | 26765219 | STAT4 TT of rs925847 is a potential genomic biomarkers for predicting lower pulmonary function. |
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| 18 | SCGB3A2 | rs6882292 | A/G | G | 2KB Upstream Variant | Asthma | Korean population | 28422086 | The promoter SNPs (rs6882292) of SCGB3A2 gene may contribute to susceptibility to asthma in a Korean population. |
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| 19 | SCGB3A2 | rs1368408 | A/G | A | 2KB Upstream | Asthma | Korean population | 28422086 | The promoter SNPs (rs1368408) of SCGB3A2 gene may contribute to susceptibility to asthma in a Korean population. |
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| 20 | SLC38A10 | rs11150780 | A/G/T | A | Intron Variant | Atopic Dermatitis | Chinese Han population | 30915103 | rs11150780 on 17q25.3 showed suggestive association with Atopic Dermatitis. |
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| 21 | SMAD3 | rs56062135 | C/T | C | Intron Variant | Asthma, Allergic Diseases | European population | 29785011 | rs56062135 was associated with asthma and allergic diseases. |
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| 22 | SLC25A46, TMEM232 | rs7705653 | A/G | A | - | Asthma, Allergic Diseases | European population | 29785011 | rs7705653 was associated with asthma and allergic diseases. |
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| 23 | STAT6 | rs1059513 | A/G (REV) | A | Non Coding Transcript Variant | Asthma, Allergic Diseases | European population | 29785011 | rs1059513 was associated with asthma and allergic diseases. |
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| 24 | SLC7A10 | rs10414065 | C/T | C | - | Asthma, Allergic Diseases | European population | 29785011 | rs10414065 was associated with asthma and allergic diseases. |
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| 25 | SLC9A4 | rs13018263 | C/T | T | Intron Variant | Asthma | - | 27554816 | rs13018263 is an eQTL for IL18RAP gene which is significantly associated with asthma risk. |
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| 26 | SMAD3 | rs17293632 | C/T | C | Intron Variant | Asthma | - | 27554816 | rs17293632 is an eQTL for SMAD3 gene which is significantly associated with asthma risk. |
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| 27 | SAFB | rs9268853 | C/T | T | - | Asthma | - | 27554816 | rs9268853 is an eQTL for SAFB gene which is significantly associated with asthma risk. |
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| 28 | SLC44A4 | rs9275141 | G/T | G | - | Asthma | - | 27554816 | rs9275141 is an eQTL for SLC44A4 gene which is significantly associated with asthma risk. |
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| 29 | STAT1 | rs3771300 | A/C (REV) | A | Intron Variant | Atopy | German population | 17983380 | The polymorphism C39134A (rs3771300), located in a potentially cis acting regulatory element in STAT1 intron 24, was inversely related to atopy measured by skin prick test, total and specific serum IgE levels. STAT1 SNP C39134A may protect from atopic sensitization. |
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| 30 | STAT3 | G3363a16 | G/T | - | - | Asthma | Caucasian population | 15935090 | G3363a16 was significantly associated with baseline FEV1: homozygotes for the minor allele of the polymorphism had lower FEV1 than homozygotes for the major alleles. |
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| 31 | STAT3 | rs1026916 | A/G | A | Intron Variant | Asthma | Caucasian population | 15935090 | rs1026916 was significantly associated with baseline FEV1: homozygotes for the minor allele of the polymorphism had lower FEV1 than homozygotes for the major alleles. |
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| 32 | STAT3 | rs957971 | C/G (REV) | G | Intron Variant | Asthma | Caucasian population | 15935090 | rs957971 was significantly associated with baseline FEV1: homozygotes for the minor allele of the polymorphism had lower FEV1 than homozygotes for the major alleles. |
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| 33 | STAT3 | rs2293452 | A/G | A | Intron Variant | Asthma | Egyptian population | 21624746 | A significant association between STAT3 polymorphism (rs2293452) and asthma susceptibility in atopic asthma. |
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| 34 | SOCS1 | -1478CA > del | - | - | Deletion | Asthma | Japanese population | 17099141 | A significant association was noted between an SOCS1 promoter polymorphism -1478CA > del and adult asthma. |
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| 35 | SOCS1 | rs243327 | C/T (REV) | C | Intron Variant | Asthma | Japanese population | 17099141 | There was a positive association in the genotype frequency of –3969C>T of the SOCS1 gene and the most severe cases of adult asthma in an allelic test. |
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| 36 | SPATS2L | rs295137 | A/G (REV) | G | - | Asthma | African population, European population | 24369795 | The minor allele of rs295137 in SPATS2L was associated with a greater acute SABA bronchodilator response in asthmatics and is more common in an African population compared to populations of European descent. |
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| 37 | SPATS2L | rs295114 | A/G (REV) | G | Intron Variant | Asthma | Non Hispanic White population | 24369795 | rs295114 in SPATS2L was associated with the acute bronchodilator response to SABA in asthmatics. |
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| 38 | SMAD3 | rs17294280 | A/G | A | Intron Variant | Asthma with Hay Fever | European population, American population, Australian population | 24388013 | The rs17294280:G allele was associated with increased asthma with hay fever risk. |
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| 39 | SLC25A46 | rs3853750 | A/G (REV) | A | - | Asthma with Hay Fever | European population, American population, Australian population | 24388013 | rs3853750 was associated with asthma with hay fever risk at a suggestive significance level. |
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| 40 | SOCS3 | rs9914220 | C/T | C | Intron Variant | Childhood Asthma | Chinese population | 31539147 | The polymorphism of the SOCS3 gene rs9914220 site is correlated with the onset of childhood asthma. |
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| 41 | SOCS3 | rs4969170 | A/G | A | Intron variant | Infantile Asthma | Chinese Han population | 26464723 | Compared with GG/GA genotype in SOCS3 rs4969170, AA genotype obviously increased the susceptibility to asthma in children. |
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| 42 | SOCS3 | rs4969168 | A/G | A | 3 Prime UTR Variant | Infantile Asthma | Chinese Han population | 26464723 | Differently in rs4969168, AG and AG/GG genotypes distributions had significant differences in the patient and control groups. |
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| 43 | STAT3 | rs2293452 | A/G | A | Intron Variant | Asthma | Egyptian population | 21624746 | Polymorphism of STAT3 (rs2293452) may be useful as a new DNA-based diagnostic biomarker for identifying high-risk children susceptible to asthma. |
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| 44 | SPP1 | rs1126616 | C/G/T | C | Synonymous Variant | Asthma | Puerto Rican population | 22276228 | Haplotype analysis identified rs1126616C-rs1126772A-rs9138A to be associated with an increased risk for asthma, severity of asthma and asthma in subjects with elevated IgE. |
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| 45 | SPP1 | rs1126772 | A/G | A | 3 Prime UTR Variant | Asthma | Puerto Rican population | 22276228 | Haplotype analysis identified rs1126616C-rs1126772A-rs9138A to be associated with an increased risk for asthma, severity of asthma and asthma in subjects with elevated IgE. |
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| 46 | SPP1 | rs9138 | A/C/T | A | 3 Prime UTR Variant | Asthma | Puerto Rican population | 22276228 | Haplotype analysis identified rs1126616C-rs1126772A-rs9138A to be associated with an increased risk for asthma, severity of asthma and asthma in subjects with elevated IgE. |
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| 47 | STAT6 | GT polymorphism | - | - | - | Asthma | - | 23861779 | S allele (GT13 and GT14) of the GT repeat polymorphism confers significant risks to asthma. |
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| 48 | STAT6 | rs71802646 | - | - | - | Asthma | - | 24952213 | Short GT repeats of rs71802646 in STAT6 contribute to higher risk for asthma. |
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| 49 | STAT6 | rs324015 | A/G (REV) | A | Non Coding Transcript Variant | Asthma | - | 24952213 | rs324015 may have a protective effect on atopic asthma. |
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| 50 | STAT6 | rs3024974 | C/T (REV) | C | Intron Variant | Asthma | Chinese population | 17883727 | STAT6 C1570T polymorphism may influence lung function growth in asthmatic children. |
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| 51 | SOD3 | rs1799895 | C/G | C | Missense Variant | Allergic Airway Inflammation | American population | 28878123 | The R213G polymorphism (rs1799895) in SOD3 protects against allergic airway inflammation. |
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| 52 | SPINK5 | G-206A | G/A | - | - | Asthma | Chinese Han population | 25419437 | The -206G>A polymorphism in the SPINK5 is associated with asthma susceptibility in a Chinese Han population. |
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| 53 | ST2 | -26999G/A | A/G | - | - | Atopic Dermatitis | Japanese population | 16118232 | A significant genetic association was observed between Atopic Dermatitis and the -26999G/A single nucleotide polymorphism in the distal promoter of ST2 gene. |
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| 54 | SIGLEC8 | rs36498 | C/G/T | T | - | Allergic Asthma | Iranian population | 32077788 | The rs36498 showed significant association with allergic asthma and the T allele was found as a protective allele. |
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| 55 | STAT6 | G2964A | A/G | | 3 Prime UTR Variant | Allergy (Nut Allergy) | Caucasian population | 12058257 | STAT6 3'UTR G2964A polymorphism is associated with susceptibility and severity in nut allergic patients. |
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| 56 | STAT6 | rs324015 | A/G (REV) | A | Non Coding Transcript Variant | Allergy (Cow Milk Allergy) | Turkish population | 23535094 | The age of tolerance development for cow milk was significantly higher in children with the GG genotype at rs324015 of the STAT6 gene compared with those with the AA+AG genotype. |
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