Browse Result

Total number of records for in T of in DAAB (Version-2) database: 139

Record no	GENE NAME	SNP ID	CHANGES	ANCESTRAL ALLELES	FUNCTIONAL CONSEQUENCES	DISEASE	POPULATION	Pubmed ID	Comments
1	TLR1	rs4833095	C/T	C	Missense Variant	Asthma, Allergic rhinitis, Atopic dermatitis	Taiwanese population	25825356	Toll-like receptor-1 (TLR1) rs4833095 (N248S) variant, common in the Taiwanese population, contributes to pathogenesis of allergy. TLR1 N248S polymorphism might play a role in Th1/Th2 differentiation and the determination of serum IgE levels.
2	TBXA2R	rs1131882	A/G	G	Synonymous Variant	Asthma	Pakistani population	29588858	The minor allele A of rs1131882 in TBXA2R gene showed association with protection from asthma. AA homozygotes were more observed in controls as compared to asthmatics.
3	TNFSF4	rs1234313	A/G	A	Intron Variant	Childhood Asthma	Han Chinese population	27088737	TNFSF4 (rs1234313) was significantly correlated with Asthma and Allergic Rhinitis. The AA genotype and the A allele of rs1234313 increased the risk of both asthma and AR, while the AG genotype decreased the risk of asthma without allergic rhinitis but increased the risk of asthma with comorbid AR.
4	TNFSF4	rs1234314	A/C/G	G	Intron Variant	Childhood Asthma	Han Chinese population	27088737	TNFSF4 (rs1234314) was significantly correlated with Asthma and Allergic Rhinitis. With regard to rs1234314, the CG genotype and the C allele are protective factors for asthma without allergic rhinitis, while the CC genotype and the C allele provide protection for asthma with comorbid AR.
5	TNFSF4	rs1234315	C/T	C	Intron Variant	Childhood Asthma	Han Chinese population	27088737	TNFSF4 (rs1234315) was significantly correlated with Asthma and Allergic Rhinitis. Significant association between the CT genotype and the C allele of rs1234315 and susceptibility to both asthma and AR, while the CC genotype decreased the risk only for asthma with comorbid AR.
6	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Asthma, Exposure to air pollutants	African Children	27001655	The TNFα -308 (G/A) polymorphism may be associated with increased pollutant-associated effects on FEV1 intraday variability for both SO2 and NO. The A allele may increase susceptibility to the adverse effects of air pollutants.
7	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Asthma	West Asian population	30176222	TNF-α - 308 G/A polymorphism was significantly correlated with the risk of asthma in West Asians.
8	TNFalpha	rs1799724	C/T	C	2KB Upstream Variant	Asthma	Caucasian population	30176222	TNF-α - 857C/T polymorphism was significantly correlated with the risk of asthma in Caucasians.
9	TNFalpha	rs1800630	A/C	C	2KB Upstream Variant	Asthma	East Asian population	30176222	TNF-α - 863C/A polymorphism was significantly correlated with the risk of asthma in East Asians.
10	TNFalpha	rs361525	A/G	G	2KB Upstream Variant	Asthma	Caucasian population	30176222	TNF-α - 238 G/A polymorphism was significantly correlated with the risk of asthma in Caucasians.
11	TNFalpha	rs1799964	C/T	C	2KB Upstream Variant	Asthma	Caucasian population, East Asian population	30176222	TNF-α - 1031 T/C polymorphism was significantly correlated with the risk of asthma in Caucasians and East Asians.
12	TSLP	rs2289278	C/G	C	Intron Variant	Atopic Dermatitis	Han Chinese ethnicity, British Isle of Wight birth cohort	26712523	The TSLP rs2289278 CC genotype increased the risk of Atopic Dermatitis (AD). In children sensitized to certain allergens, a genetic predisposition (rs2289278 genotype CC) significantly increased the risk of AD.
13	TSLP	rs2289278	C/G	C	Intron Variant	Atopic Dermatitis, Asthma	Han Chinese ethnicity, British Isle of Wight birth cohort	26712523	The rs2289278 C allele significantly increased the risk of developing asthma in Atopic Dermatitis patients.
14	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Diisocyanate induced Asthma (DA)	Caucasian French Canadians	25721048	In a dominant model, the TGFB1 rs1800469 SNP was associated with a protection against Diisocyanate induced Asthma (DA).
15	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Diisocyanate induced Asthma (DA)	Caucasian French Canadians	25721048	In a dominant model, TNFalpha rs1800629 SNP conferred an increased risk of Diisocyanate induced Asthma (DA).
16	TLR10	rs4129009	A/C/G/T	A	Missense Variant	Childhood Asthma	Finnish population	28592890	Current asthma was more common in children with the variant AG or GG genotype in the TLR10 rs4129009 gene versus those who were homozygous for the major allele A. Polymorphism in the TLR10 gene increases the risk of asthma in preschool-aged children after infant bronchiolitis.
17	TLR7	rs179008	A/C/T	A	Missense Variant	Childhood Asthma	Finnish population	28592890	Asthma was more common in girls with the TLR7 variant AT or TT genotype versus those who were homozygous for the major allele A. Polymorphism in the TLR7 gene may increase the risk of asthma in preschool-aged children after infant bronchiolitis.
18	TLR2	rs4696480	A/T	T	Intron Variant	Asthma	-	28514297	TLR2 rs4696480 polymorphism is significantly associated with asthma susceptibility and the TLR2 rs4696480 polymorphism is a risk factor for asthma.
19	TAS2R14	-	-	-	-	Asthma	Korean population	26812163	Increased airway reversibility and bronchodilator response (BDR) was significantly associated with SNPs of -815T>C of the TAS2R14 gene. There was a significant association between -815T>C and a low mean Asthma Control Test (ACT) score.
20	TAS2R14	-	-	-	-	Asthma	Korean population	26812163	Increased airway reversibility and bronchodilator response (BDR) was significantly associated with SNPs of -1267A>G of the TAS2R14 gene.
21	TAS2R14	-	-	-	-	Asthma	Korean population	26812163	Increased airway reversibility and bronchodilator response (BDR) was significantly associated with SNPs of -1897T>C of the TAS2R14 gene.
22	TSLP, SLC25A46	rs10056340	G/T	T	5' Upstream Non Coding Variant, 3' Downstream Non Coding Variant	Asthma	American Indian population	28668238	One SNP at 5q22.1, rs10056340, showed a significant association with case-control status following Bonferroni adjustment for ten comparisons, considering either the major or minor allele in a dominant model. This SNP was significantly associated with asthma and atopy.
23	TIM3	rs10515746	A/C/T	C	2KB Upstream Variant	Asthma	Iranian population	28865412	TIM-3 -574 G>T polymorphism was found to be greatly associated with the susceptibility of Iranian population to asthma.
24	TIM3	rs1036199	A/C	A	Missense Variant	Asthma	Iranian population	28865412	TIM-3 +4259 T>G polymorphism was found to be greatly associated with the susceptibility of Iranian population to asthma.
25	TLR2	rs3804099	C/T	C	Synonymous Variant	Asthma	-	28858111	rs3804099 of TLR2 was significantly associated with asthma risk.
26	TLR4	rs4986791	C/T	C	Missense Variant	Asthma	-	28858111	rs4986791 of TLR4 was significantly associated with asthma risk.
27	TLR6	rs1039559	G/A	A	Intron Variant	Early Onset Asthma	Tasmanian population	28262750	Carriers of the TLR6-rs1039559 T-allele were associated with lower risk of early-onset asthma.
28	TLR6	rs5743810	G/A	G	Missense Variant	Early Onset Asthma	Tasmanian population	28262750	Carriers of the TLR6-rs5743810 C-allele were associated with lower risk of early-onset asthma.
29	TGFB1	rs2241715	C/A	A	Intron Variant	Childhood Asthma	Chinese population	28262390	Compared with the controls, patients were found to have significantly lower frequencies of genotype AA of rs2241715. For patients with severe asthma, those with genotype AA/AG of rs2241715 had remarkably higher FEV1% as compared with those with genotype GG.
30	TLE4	rs2378383	A/G/C/T	A	-	Childhood Asthma	Chinese population	28262390	Compared with the controls, patients were found to have significantly higher frequency of genotype GG of rs2378383. Genotype GG/GA of rs2378383 had remarkably lower FEV1% as compared with those with genotype AA.
31	TAP1	rs1135216	A/G (REV)	G	Missense Variant	Atopic Diseases (Asthma, Rhinitis, Dermatitis)	Asian population, African population	29416713	rs1135216 polymorphism may contribute to atopic diseases susceptibility in Asians and African population.
32	TAP1	rs1057141	A/G (REV)	G	Missense Variant	Atopic Diseases (Asthma, Rhinitis, Dermatitis)	African population	29416713	Increased risk of atopic disease in the allelic, dominant and heterozygous model for rs1057141 was found in African population.
33	TGFB1	rs1800469	C/T (REV)	C	2KB Upstream Variant	Childhood Asthma	Chinese population	29958018	The -509C/T polymorphism of the TGFB1 gene might be a risk factor for asthma in the Chinese population.
34	TBXA2R	rs4523	C/T (REV)	C	Synonymous Variant	Asthma	Asian population	27058349	TBXA2R +924C/T polymorphism is associated with asthma risk.
35	TBXA2R	rs1131882	A/G	G	Synonymous Variant	Aspirin Intolerant Asthma (AIA)	Asian population	27058349	TBXA2R +795C/T polymorphism is associated with aspirin-intolerant asthma (AIA).
36	TRPV4	rs6606743	A/G	G	Intron Variant	Bronchial Asthma	-	27599507	rs6606743 SNP was found to significantly contribute to the development of osmotic airway hyperresponsiveness. Substantial prevalence of AG + GG genotype frequency in the group of patients with asthma with osmotic hyperresponsiveness in comparison with the patients who had negative response to bronchoprovocation. Carriers of GG or AG genotypes had significantly more profound decrease of lung function parameters in relation to A homozygous patients.
37	TLR1	rs17616434	C/T	C	-	Asthma, Rhino Conjunctivitis	Sicilian children	30646946	Current Asthma was modestly associated with rs17616434.
38	TACR1, GAPDHP59	rs2287231	A/G	A	Intergenic Variant	Diisocyanate Induced Asthma	European population	29969634	rs2287231, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells.
39	TERC	rs6793295	C/G/T	C	Missense Variant	Asthma, Allergic Rhinitis	European population	26720789	A highly significant association of rs6793295 with asthma was observed. An association was noted between rs6793295 and allergic rhinitis.
40	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Asthma	Serbian population	27627560	The polymorphism C-509T (rs1800469) may be associated with asthma and disease exacerbations.
41	TLR3	rs7657186	A/G	G	Intron Variant	Asthma	Chinese Han population	27682462	The A mutation of rs7657186 was associated with alleviated inflammation. Significant association was observed between eosinophil counts and rs7657186. This polymorphism in TLR3 is associated with asthma-related symptoms but not with asthma risk.
42	TLR3	rs3775292	C/G (REV)	C	Intron Variant	Asthma	Chinese Han population	27682462	The C mutation of rs3775292 was associated with alleviated inflammation. The CC genotype of rs3775292 had significantly lower FEV1%. Significant association was observed between eosinophil counts and rs3775292. This polymorphism in TLR3 is associated with asthma-related symptoms but not with asthma risk.
43	TLR3	rs3775291	A/C/G (REV)	G	Missense Variant	Asthma	Chinese Han population	27682462	The T mutation of rs3775291 was associated with aggravated inflammation. rs3775291 was associated with total serum IgE levels. Significant association was observed between eosinophil counts and rs3775291. This polymorphism in TLR3 is associated with asthma-related symptoms but not with asthma risk.
44	TLR3	rs7668666	A/C/T	C	Intron Variant	Asthma	Chinese Han population	27682462	rs7668666 was associated with total serum IgE levels. This polymorphism in TLR3 is associated with asthma-related symptoms but not with asthma risk.
45	TLR3	rs3775296	G/T (REV)	G	5 Prime UTR Variant	Asthma	Chinese Han population	27682462	The AA genotype of rs3775296 had significantly lower FEV1%. rs3775296 was associated with total serum IgE levels. This polymorphism in TLR3 is associated with asthma-related symptoms but not with asthma risk.
46	TLR3	rs13126816	A/G	G	Intron Variant	Asthma	Chinese Han population	27682462	The A mutation of rs13126816 was associated with aggravated inflammation. Significant association was observed between eosinophil counts and rs13126816. This polymorphism in TLR3 is associated with asthma-related symptoms but not with asthma risk.
47	TLR2	rs3804099	C/T	C	Synonymous Variant	Asthma	Puerto Rican population	27495363	The TLR2 +596C/T SNP was found to be significantly associated to asthma particularly to females.
48	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Atopic Diseases (Asthma, Rhinitis, Dermatitis)	Croatian population	27240833	Compared to the control subjects, univariate analysis showed a significant negative association of the TNFalpha -308G>A polymorphism with atopic asthma, atopic dermatitis, asthma and skin symptoms and positive SPT.
49	TRPA1	rs959974	G/T	T	Intron Variant	Childhood Asthma	-	27779810	There was strong evidence for association between rs959974 and asthma.
50	TRPA1	rs1384001	A/C	A	Intron Variant	Childhood Asthma	-	27779810	There was strong evidence for association between rs1384001 and asthma.
51	TRPA1	rs3735945	C/T	C	Intron Variant	Childhood Asthma	-	27779810	There was strong evidence for association between rs3735945 and asthma.
52	TRPA1	rs920829	A/G (REV)	G	Missense Variant	Childhood Asthma	-	27779810	There was strong evidence for association between rs920829 and asthma.
53	TRPA1	rs7010969	A/C	C	Intron Variant	Childhood Asthma	-	27779810	There was strong evidence for association between rs7010969 and asthma.
54	TRPA1	rs4738202	A/G	G	Intron Variant	Childhood Asthma	-	27779810	There was strong evidence for association between rs4738202 and asthma.
55	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Asthma	-	27717847	TGFB1 C-509T (rs1800469) polymorphism may be risk factor for asthma.
56	TGFB1	rs1982073	C/G/T (REV)	C	Missense Variant	Asthma	-	27717847	TGFB1 T869C (rs1982073) polymorphism may be risk factor for asthma.
57	TIM1	rs9313422	A/C/G/T	C	Intron Variant	Asthma	Asian population	28434117	TIM-1-416G>C single nucleotide polymorphism is associated with asthma susceptibility for the Asian ethnicity.
58	TLR1	rs5743618	G/T (REV)	T	Missense Variant	Postbronchiolitis Asthma	Finnish population	28692144	Polymorphism in TLR1 gene (rs5743618) may increase the risk of asthma at 11-13 years after infant bronchiolitis.
59	TLR10	rs4129009	A/C/G/T (REV)	A	Missense Variant	Postbronchiolitis Asthma	Finnish population	28692144	Polymorphism in TLR10 gene (rs4129009) may increase the risk of asthma at 11-13 years after infant bronchiolitis.
60	TLR2	rs5743708	A/G	G	Missense Variant	Atopic Dermatitis	Caucasian population	30273064	The heterogeneous "GA" genotype of the TLR2 rs5743708 may be associated with increased susceptibility to atopic dermatitis in Caucasians.
61	TLR4	rs4986790	A/G/T	A	Missense Variant	Atopic Dermatitis	Caucasian population	30273064	The heterogeneous "AG" genotype of the TLR4 rs4986790 may be associated with increased susceptibility to atopic dermatitis in Caucasians.
62	TRPM3	rs10780946	C/T	C	Intron Variant	Aspirin Exacerbated Respiratory Disease (AERD)	Mexican mestizo population.	26891941	rs10780946 TRPM3 polymorphism is associated with AERD susceptibility.
63	TLR7	rs179009	A/C/T (REV)	T	Intron Variant	Pediatric Asthma	-	30373864	The genotype at TLR7 rs179009 was significantly different between asthmatics and healthy subjects.
64	TLR9	rs187084	C/T (REV)	C	2KB Upstream Variant	Pediatric Asthma	-	30373864	The genotype at TLR9 rs187084 was significantly different between asthmatics and healthy subjects.
65	TNFalpha	rs1800630	A/C	C	2KB Upstream Variant	Bronchitis	Greenlandic population	28740106	TNFalpha SNP (rs1800630) was exclusively associated with bronchitis within the Greenlandic population.
66	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Bronchitis	Greenlandic population	28740106	TNFalpha SNP (rs1800629) was exclusively associated with bronchitis within the Greenlandic population.
67	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Asthma	-	27081784	A correlation between the C-509T SNP (rs1800469)of the TGFB1 gene and IL5 mRNA expression was demonstrated in asthmatics.
68	TGFB1	rs1800470	C/G/T (REV)	C	Missense Variant	Allergic Asthma and Helminth Infection (In Children)	African Admixed population	28284979	An association between rs1800470 (C allele) and atopic wheezing and markers of allergy was noted. A positive association was observed between the haplotype ACCA and Trichuris trichiura infection and Ascaris lumbricoides infection. This haplotype was also associated with increased IL10 production. Individuals with TGFB1 polymorphisms have an increased susceptibility to helminth infections and a lower risk of developing allergy.
69	TSLP	rs1837253	C/T	T	-	Asthma	Puerto Rican population	28461288	rs1837253 was found to be associated with asthma.
70	TIRAP	rs8177374	C/T	C	Missense Variant	Asthma	Caucasian population, African American population	30140039	The onset of asthma may be delayed in individuals with at least one copy of the minor TIRAP allele of rs8177374.
71	TSLP	rs1837253	C/T	T	-	Asthma, Allergic Diseases	European population	29785011	rs1837253 was associated with asthma and allergic diseases.
72	TLR10	rs28393318	A/G	G	Intron Variant	Asthma, Allergic Diseases	European population	29785011	rs28393318 was associated with asthma and allergic diseases.
73	TLR3	rs1879026	A/C/G (REV)	C	Intron Variant	Allergic Bronchopulmonary Aspergillosis (ABPA)	Caucasian population	27708669	Compared to atopic asthmatics, ABPA patients were more likely to be carriers of the common G allele and common GG genotype of the intronic SNP in TLR3 (rs1879026).
74	TLR1	rs12233670	C/T	T	-	Asthma	-	27554816	rs12233670 is an eQTL for TLR1 gene which is significantly associated with asthma risk.
75	TINF2	rs3135006	A/G (REV)	G	-	Asthma	-	27554816	rs3135006 is an eQTL for TINF2 gene which is significantly associated with asthma risk.
76	TAP2	rs2858312	C/G (REV)	C	-	Asthma	-	27554816	rs2858312 is an eQTL for TAP2 gene which is significantly associated with asthma risk.
77	TSLP	rs17132582	A/G	G	-	Asthma	-	27554816	rs17132582 is an eQTL for TSLP gene which is significantly associated with asthma risk.
78	TMCC2	rs1668873	C/T (REV)	G	Intron Variant	Asthma	-	27554816	rs1668873 is an eQTL for B4GALT3 gene which is significantly associated with asthma risk.
79	TLR4	rs4986791	C/T	C	Missense Variant	Nasal Polyposis with Asthma	Turkish population	31304782	rs4986791 of TLR4 (1196 C>T) genotype was more frequent in nasal polyposis group than control group. The frequencies of the TLR4 (1196 C>T) CT and TT genotypes were higher in asthmatic patients as compared with those without asthma. It was observed that the probability of nasal polyposis was 62.7% in presence of TLR4 (1196 C>T) polymorphism with asthma.
80	TLR4	rs1927911	C/T (REV)	T	Intron Variant	Allergic Rhinitis	Swedish population, Canadian population, German population, Dutch population	23639307	Children carrying a minor rs1927911 (TLR4) allele may be at a higher risk of allergic rhinitis.
81	TNF	rs1800629	A/G	G	2KB Upstream Variant	Allergic Rhinitis	Swedish population, Canadian population, German population, Dutch population	23639307	Children carrying a minor rs1800629 (TNF) allele may be at a higher risk of allergic rhinitis.
82	TRPV1	rs222747	A/C/G/T (REV)	C	Missense Variant	Asthma	American Indian/Alaskan Native population, Asian population, Black/African American population, Native Hawaiian/Pacific Islander population, White/Caucasian population	27758864	I315M variants (rs222747) were associated with worse asthma symptom control with the effects of I315M manifesting in mild asthma.
83	TRPV1	rs8065080	C/T	C	Missense Variant	Asthma	American Indian/Alaskan Native population, Asian population, Black/African American population, Native Hawaiian/Pacific Islander population, White/Caucasian population	27758864	The percentages of subjects with wild-type TRPV1 and I585V/V (rs8065080) were lower among individuals with poor asthma control. I585V variants (rs8065080) were associated with worse asthma symptom control with the effects of the I585V variant manifesting in severe, steroid-insensitive individuals.
84	TNS1	rs76043829	A/G	G	Intron Variant	Asthma with Hay Fever	European population, American population, Australian population	24388013	This single nucleotide polymorphism showed suggestive evidence for association with asthma with hay fever risk.
85	TLR1	rs4833095	C/T	C	Missense Variant	Asthma with Hay Fever	European population, American population, Australian population	24388013	The rs4833095:T allele was associated with increased asthma with hay fever risk.
86	TSLP	rs1837253	C/T	T	-	Asthma with Hay Fever	European population, American population, Australian population	24388013	The rs1837253:C allele was associated with increased asthma with hay fever risk.
87	TNFAIP3	rs9494885	C/T	C	-	Allergic Rhinitis	Chinese Han population	26996111	The rs9494885 TC genotype and C allele were more frequent in Allergic Rhinitis patients compared with controls. The frequencies of the rs9494885 TT genotype and T allele were lower in AR patients than that in controls.
88	TNFAIP3	rs7753873	A/C	C	-	Allergic Rhinitis	Chinese Han population	26996111	A higher frequency of the rs7753873 AC genotype and C allele and a lower frequency of the rs7753873 AA genotype and A allele were observed in Allergic Rhinitis patients as compared to healthy controls.
89	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Childhood Allergic Rhinitis	Chinese population	21055322	TGFB1 gene polymorphism -509C/T may play a potential role in the severity of persistent Allergic Rhinitis in childhood.
90	TGFB1	rs747857	C/G/T (REV)	G	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs747857 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
91	TGFB1	rs6508975	A/C/T	C	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs6508975 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
92	TGFB1	rs2241715	G/T (REV)	T	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs2241715 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
93	TGFB1	rs12462166	C/T	C	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs12462166 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
94	TGFB1	rs12983775	A/G	A	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs12983775 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
95	TGFB1	rs1800470	C/G/T (REV)	C	Missense Variant	Allergic Rhinitis	Chinese population	26791767	rs1800470 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
96	TGFB1	rs2317130	C/G/T	C	2KB Upstream Variant	Allergic Rhinitis	Chinese population	26791767	rs2317130 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
97	TGFB1	rs11466359	C/G/T (REV)	C	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs11466359 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
98	TGFB1	rs12461895	A/C	C	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs12461895 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
99	TGFB1	rs7258445	A/C/G	A	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs7258445 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
100	TGFB1	rs11466345	A/G (REV)	G	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs11466345 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
101	TGFB1	rs2241717	C/G/T (REV)	T	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs2241717 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
102	TLR4	rs4986790	A/G/T	A	Missense Variant	Atopic Dermatitis	Ukrainian population	23821954	TLR4 gene mutant allele 896G is detected more frequently in children with Atopic Dermatitis with increased susceptibility to acute viral respiratory infections as compared to the control group.
103	TLR4	rs10759930	C/T	C	-	Allergic Rhinitis	Chinese population	29798160	Heterozygous and homozygous allele in rs10759930 is associated with allergic rhinitis.
104	TLR4	rs1927911	C/T (REV)	T	Intron Variant	Allergic Rhinitis	Korean population	25840711	The risk for the development of Allergic Rhinitis or atopic Allergic Rhinitis subjects with the TLR4 CC genotype were highest when all the 3 early-life factors were present.
105	TSLP	rs1898671	C/T	C	Intron Variant	Allergic Rhinitis	-	26629072	TSLP rs1898671 polymorphism was associated with a higher risk for allergic rhinitis.
106	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Atopic Dermatitis	Saudi Arabian population	29887728	TNFalpha rs1800629 (−308 G/A) polymorphism is associated with the susceptibility and can be a risk factor for Atopic Dermatitis.
107	TNFbeta	rs909253	A/C/T (REV)	T	Intron Variant	Atopic Dermatitis	Saudi Arabian population	29887728	TNFbeta rs909253 (+ 252 A/G) polymorphism is associated with the susceptibility and can be a risk factor for Atopic Dermatitis.
108	TGFB1	rs1800471	A/C/G (REV)	G	Missense Variant	Allergic Rhinitis	Iranian population	26316419	The C allele and the CG genotype in rs1800471 in TGFB1 were associated with a higher susceptibility to Allergic Rhinitis. C/C and T/C haplotypes (rs1982037, rs1800471) in TGFB1 gene and A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL10 gene were found with higher frequencies in patients than controls.
109	TGFB1	rs1982037	A/G (REV)	G	-	Allergic Rhinitis	Iranian population	26316419	C/C and T/C haplotypes (rs1982037, rs1800471) in TGFB1 gene and A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL10 gene were found with higher frequencies in patients than controls.
110	TNFSF10	rs12488654	A/G	G	2KB Upstream Variant	Bronchial Asthma	Caucasian population	20961336	Combinations of SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) in the TNFSF10 allele were strongly associated with asthma.
111	TNFSF10	rs3136586	A/G (REV)	G	2KB Upstream Variant	Bronchial Asthma	Caucasian population	20961336	Combinations of SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) in the TNFSF10 allele were strongly associated with asthma.
112	TNFSF10	rs3136598	G/T (REV)	T	Intron Variant	Bronchial Asthma	Caucasian population	20961336	Combinations of SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) in the TNFSF10 allele were strongly associated with asthma.
113	TNFSF10	rs3136604	A/C/T (REV)	C	Intron Variant	Bronchial Asthma	Caucasian population	20961336	Combinations of SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) in the TNFSF10 allele were strongly associated with asthma.
114	TLR2	rs3804100	C/T	T	Synonymous Variant	Allergic Asthma	Norwegian population	19148143	Both Type 1 Diabetes and allergic asthma were significantly associated with the TLR2 rs3804100 T allele and further associated with the haplotype including this SNP, possibly representing a susceptibility locus common for the two diseases.
115	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Asthma	Asian population, Caucasian population, Mixed population	21082225	TNFalpha -308 G/A polymorphism contributes to susceptibility to asthma.
116	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Asthma	Asian population, Caucasian population, Mixed population	31161819	There was a strong association between the TNFalpha gene promoter polymorphism (-308G/A) and the development to asthma in both children and adults.
117	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Bronchial Asthma	Egyptian population	30600954	TNFalpha genetic polymorphism (-308G/A) could have a role in the development of bronchial asthma among Egyptian children.
118	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Asthma	-	25668892	TNFalpha -308A/G polymorphism is a risk factor for asthma.
119	TNFalpha	rs1799724	C/T	C	2KB Upstream Variant	Asthma	-	25668892	TNFalpha -857C/T polymorphism is a risk factor for asthma.
120	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Asthma	-	24936650	The rs1800629 polymorphism in TNF-α was a risk factor for asthma.
121	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Asthma	Korean population	17196641	The TNFalpha promoter polymorphism rs1800629 (-308G/A) might be associated with severe broncho hyperresponsiveness in Korean children with asthma.
122	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Childhood Asthma	Egyptian population	23376082	Genetic variation in TNF-α-308G/A may contribute to childhood asthma and wheezing.
123	TNFalpha	rs1800630	A/C	C	2KB Upstream Variant	Asthma	Indian population	16728705	The TNFA-863C > A polymorphism in the promoter region of TNFA may influence TNF-alpha expression and affect TsIgE levels and susceptibility to asthma.
124	TLR4	rs4986790	A/G/T	A	Missense Variant	Asthma	-	25729620	TLR4 Asp299Gly (rs4986790) might contribute significantly to asthma susceptibility.
125	TLR2	rs5743708	A/G	G	Missense Variant	Asthma	-	25729620	TLR2 Arg753Gln (rs5743708) might contribute significantly to asthma susceptibility.
126	TLR9	rs5743836	C/T (REV)	C	2KB Upstream Variant	Asthma	-	25729620	TLR9-1237 (rs5743836) might contribute significantly to asthma susceptibility.
127	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Asthma	Chinese population	24944803	TGFB1 C-509T (rs1800469) had the potential to modify the childhood asthma risk and the association showed no notable difference with the disease severity.
128	TSLP	rs3806933	A/C/T	T	Non Coding Transcript Variant	Bronchial Asthma	Japanese population	20656951	The promoter polymorphism rs3806933 was significantly associated with disease susceptibility in both childhood atopic and adult asthma.
129	TSLP	rs2289276	C/T	C	Intron Variant	Bronchial Asthma	Japanese population	20656951	The promoter polymorphism rs2289276 was significantly associated with disease susceptibility in both childhood atopic and adult asthma.
130	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Asthma	American population	14597484	The T allele of C-509T (rs1800469) is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription.
131	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Bronchial Asthma	North Indian population	16393721	An association between TNF-alpha G-308A (rs1800629) and asthma was noted in the North Indian population.
132	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Allergic Rhinitis	Chinese population	32216462	Polymorphism -509C/T (rs1800469) in TGFB1 promoter is associated with increased risk and severity of persistent Allergic Rhinitis in Chinese Population.
133	TIM4	G8570A	A/G	-	-	Allergic Asthma	Chinese Han population	17407086	The polymorphism of 8570G > A in TIM4 may be associated with allergic asthma in the population of Han nationality from Hubei province of China.
134	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Allergy	Jewish population	16179826	C to T base change in TGFB1 SNP C-509T (rs1800469) has been associated with a higher risk of allergy.
135	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Childhood Asthma	Chinese Han population	19657898	IL4RA Q551R and TGF-beta1 C-509T are single nucleotide polymorphism loci with significant association to childhood asthma, but they do not have synergistic effects.
136	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Aspirin-Intolerant Asthma (AIA)	Korean population	16916603	TGFbeta1 -509C>T polymorphism was not associated with the AIA phenotype in the Korean population, but may contribute to the development of the AIA phenotype with rhinosinusitis.
137	TGFB1	rs1800469	C/T	C	2KB Upstream Variant	Aspirin-Intolerant Asthma (AIA) and Rhinosinusitis	Korean population	19222424	A synergistic effect between the TGF-beta1-509C/T and IL-10-1082A/G polymorphisms on the phenotype of AIA was noted.
138	TNFalpha	rs1800629	A/G	G	2KB Upstream Variant	Asthma	Italian Caucasian population	23527710	TNF-alpha -308A allele frequency was higher in asthmatics than in controls.
139	TNFalpha	rs361525	A/G	G	2KB Upstream Variant	Asthma	Italian Caucasian population	23527710	TNF-alpha -238A allele frequency was higher in asthmatics than in controls.