| Record no | GENE NAME | SNP ID | CHANGES | ANCESTRAL ALLELES | FUNCTIONAL CONSEQUENCES | DISEASE | POPULATION | Pubmed ID | Comments |
|---|
| 1 | VDBP | rs7041 | A/G/T | T | Missense Variant | Bronchial Asthma (In Children and Adolescents) | Egyptian Population | 30548492 | rs7041 GG genotype and G allele increased asthma risk. The control group has a higher carriage rate of T allele. |
|---|
| 2 | VDBP | rs4588 | A/C/T | C | Missense Variant | Bronchial Asthma (In Children and Adolescents) | Egyptian Population | 30548492 | rs4588 AA genotype and A allele conferred protection in the Egyptian population. The carriage rate of C allele is higher among asthma patients. |
|---|
| 3 | VEGF | rs3025020 | C/T | C | Intron Variant | Asthma | Chinese Han population | 27173321 | The T allele in rs3025020 was significantly more prevalent in the asthma group than in controls. The VEGF SNPs rs3025020 may be associated with the development of asthma, indicating the role of VEGF in asthma. |
|---|
| 4 | VEGF | rs3025039 | C/T | C | 3 Prime UTR Variant | Asthma | Chinese Han population | 27173321 | The T allele in rs3025039 was significantly more prevalent in the asthma group than in controls. The VEGF SNPs rs3025039 may be associated with the development of asthma, indicating the role of VEGF in asthma. |
|---|
| 5 | VDR | rs7975232 | A/C | C | Intron Variant | Childhood Asthma | Asian population, Non Asian population | 27551963 | The risk of developing childhood asthma was almost 1.5-fold higher in Asians with ApaI (rs7975232) G allele. |
|---|
| 6 | VDR | rs1544410 | A/C/G/T | G | Intron Variant | Childhood Asthma | - | 27551963 | BsmI (rs1544410) polymorphism marginally contributes to childhood asthma susceptibility. |
|---|
| 7 | VDR | rs2228570 | A/C/G/T | T | Initiator Codon Variant | Childhood Asthma | Caucasian population | 27551963 | The FokI (rs2228570) G allele may increase the asthma risk compared with the A allele in Caucasian population. |
|---|
| 8 | VDR | rs4328262 | A/G/T | T | Intron Variant | Viral Respiratory Illness, Asthma | European or American European | 26399222 | rs4328262 was significantly associated with variation in eight of the 10 RhinoGen phenotypes and with asthma at age 6 in the COAST (Childhood Origins of Asthma) study. Specifically, the TT genotype at rs4328262 was associated with fewer observed illnesses, decreased cold symptom burden, and less loss of asthma control in children in RhinoGen, and with less asthma at age 6 years in the COAST children. |
|---|
| 9 | VDR | rs2228570 | A/C/G/T | T | Initiator Codon Variant | Childhood Bronchial Asthma | Chinese Han ethnicity | 28590769 | Significant associations was found between rs2228570 of VDR and susceptibility to and prognosis of childhood bronchial asthma, providing novel target for treating the disorder. |
|---|
| 10 | VDR | rs7975232 | A/C | C | Intron Variant | Childhood Bronchial Asthma | Chinese Han ethnicity | 28590769 | Significant associations was found between rs7975232 of VDR and susceptibility to and prognosis of childhood bronchial asthma, providing novel target for treating the disorder. The haplotype analysis suggested that CA rs7975232 was correlated with levels of VD, IL-4, and IL-5. |
|---|
| 11 | VDR | rs1544410 | A/C/G/T | G | Intron Variant | Childhood Bronchial Asthma | Chinese Han ethnicity | 28590769 | Significant associations was found between rs1544410 of VDR and susceptibility to and prognosis of childhood bronchial asthma, providing novel target for treating the disorder. The haplotype analysis suggested that AG rs1544410 was correlated with levels of VD, IL-4, and IL-5. |
|---|
| 12 | VDR | rs2228570 | A/C/G/T(REV) | T | Initiator Codon Variant | Asthma | - | 27088875 | rs2228570 gene polymorphism in VDR is associated with increased susceptibility to asthma, indicating VDR polymorphism could be developed as biomarker for asthma susceptibility. |
|---|
| 13 | VDR | rs7975232 | A/C | C | Intron Variant | Asthma | - | 27088875 | rs7975232 gene polymorphism in VDR are associated with increased susceptibility to asthma, indicating VDR polymorphism could be developed as biomarker for asthma susceptibility. |
|---|
| 14 | VDR | rs731236 | C/T (REV) | T | Synonymous Variant | Asthma | - | 27088875 | rs731236 gene polymorphism in VDR are associated with increased susceptibility to asthma, indicating VDR polymorphism could be developed as biomarker for asthma susceptibility. |
|---|
| 15 | VDR | rs3782905 | C/G (REV) | C | Intron Variant | Asthma | - | 27088875 | rs3782905 gene polymorphism in VDR are associated with increased susceptibility to asthma, indicating VDR polymorphism could be developed as biomarker for asthma susceptibility. |
|---|
| 16 | VDR | rs7975232 | A/C | C | Intron Variant | Childhood Bronchial Asthma | Chinese population | 29456680 | The locus CC frequency of rs7975232 of VDR gene in observation group was lower in the asthma group than that in the control group; the locus AC and AA frequencies of rs7975232 of VDR gene were higher in the asthma group than those in the control group. |
|---|
| 17 | VDR | rs2228570 | A/C/G/T (REV) | T | Initiator Codon Variant | Bronchial Asthma | Serbian population | 28407346 | FF genotype and F allele of FokI SNP (rs2228570) of VDR exerts a protective role on Bronchial Asthma development in Serbian population. |
|---|
| 18 | VEGF | rs2010963 | C/G | G | 5 Prime UTR Variant | Asthma | Tunisian population | 19787077 | A borderline association with asthma was found for the G allele in the −634G > C polymorphism (rs2010963). |
|---|
| 19 | VEGF | rs2146323 | A/C | C | Intron Variant | Asthma | Slovenian population | 22519966 | Polymorphism rs2146323 A>C in VEGFA was associated with response to Inhaled Corticosteroid therapy in asthmatics. Asthma patients with the AA genotype had a greater improvement in the %predicted FEV(1) than those with the AC or CC genotype. Conversely, the AA genotype in rs2146323 was associated with uncontrolled asthma in patients regularly receiving LTRA therapy and a worse FEV(1)/FVC ratio in asthma patients who episodically used LTRA therapy. |
|---|
| 20 | VEGF | rs833058 | C/T | T | - | Asthma | Slovenian population | 22519966 | Polymorphism rs833058 C>T was associated with treatment response to episodically used LTRA therapy in asthmatics. A subgroup of asthma patients with the TT genotype had an improvement in the %predicted FEV(1) as compared with no improvement in patients with the CT or CC genotype. |
|---|
| 21 | VEGF | -2549 -2567 del18 | - | - | Deletion | Asthma | Polish population | 30574871 | The presence of del18 genotype at -2549 -2567 position in the promoter of VEGF gene along with disease duration and other factors like cigarette smoking, associate with the risk of irreversible bronchoconstriction in asthmatics. |
|---|
| 22 | VEGF | rs1479430148 | A/T | - | 3 Prime UTR Variant | Allergic Rhinitis | Malaysian Chinese population | 30215845 | AA genotype in rs1479430148 (VEGFA) was significantly associated with allergic rhinitis in mixed (pigmented-vascular) subtype. |
|---|
| 23 | VEGFA | rs2010963 | C/G | G | 5 Prime UTR Variant | Atopic Dermatitis | Korean population | 23490417 | The rs2010963 SNP had a marginally significant effect on log-eosinophil counts in atopic dermatitis patients. |
|---|
| 24 | VDR | rs2228570 | A/C/G/T | T | Initiator Codon Variant | Asthma | Australian population | 32380236 | Children with rs2228570 AA genotype had higher exacerbation severity scores (p=0.001) and poorer β2-agonist treatment response. |
|---|
| 25 | VDR | rs1544410 | A/C/G/T | G | Intron Variant | Asthma | Australian population | 32380236 | Children with rs1544410 (BsmI) TT genotype had lower exacerbation severity scores as compared to those with the CC genotype. |
|---|
| 26 | VDR | rs739837 | C/G/T | T | 3 Prime UTR Variant | Asthma | Chinese population | 32157950 | The minor allele (T) of rs739837 significantly increased the severity of asthma. |
|---|
| 27 | VDR | rs7975232 | A/C | C | Intron Variant | Allergic Rhinitis | Chinese population | 31163545 | The polymorphism of ApaⅠ(rs7975232) locus of VDR gene is correlated with Allergic Rhinitis susceptibility. |
|---|
| 28 | VDR | rs731236 | C/T (REV) | T | Synonymous Variant | Asthma | Irish population | 29384117 | TaqI polymorphism was associated with asthma in Irish children. |
|---|
| 29 | VDR | rs7975232 | A/C | C | Intron Variant | Asthma | Irish population | 29384117 | ApaI polymorphism was associated with asthma in Irish children. |
|---|
