Record no | GENE NAME | SNP ID | CHANGES | ANCESTRAL ALLELES | FUNCTIONAL CONSEQUENCES | DISEASE | POPULATION | Pubmed ID | Comments |
---|
1 | Z2BP2 | rs12936231 | C/G/T | G | Intron Variant | Childhood Asthma | Swedish population | 26786172 | rs12936231 in Z2BP2 is a high-risk genetic variant associated specifically with childhood asthma. |
---|
2 | ZPBP2, GSDMB | rs9901146 | A/G | A | - | Asthma | European Ancestry | 27130862 | rs9901146 in 17q12-q21 loci was found to be associated with time to asthma onse (TAO) at genome-wide significance levels. |
---|
3 | ZBTB16 | rs1672692 | A/G | G | Intron Variant | Diisocyanate Induced Asthma | European population | 29969634 | rs1672692, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. |
---|
4 | ZPBP2 | rs12936231 | C/G/T | G | Intron Variant | Asthma | - | 27848966 | The asthma-risk variants rs4065275 and rs12936231 switched CTCF-binding sites in the 17q21 locus and 4C-Seq assays showed that several distal cis-regulatory elements upstream of the disrupted ZPBP2 CTCF-binding site interacted with the ORMDL3 promoter region in CD4+ T cells exclusively from subjects carrying asthma-risk alleles. |
---|
5 | ZPBP2 | rs11557467 | G/T | G | Missense Variant | Asthma | Dutch population | 27439200 | rs11557467 was significantly associated with asthma. |
---|
6 | ZBTB10 | rs2136016 | A/G | G | - | Asthma, Allergic Diseases | European population | 29785011 | rs2136016 was associated with asthma and allergic diseases. |
---|
7 | ZNF707 | rs17609240 | A/G/T | T | - | Asthma | - | 27554816 | rs17609240 is an eQTL for ZNF707 gene which is significantly associated with asthma risk. |
---|
8 | ZBTB10 | rs7009110 | C/T | T | - | Asthma with Hay Fever | European population, American population, Australian population | 24388013 | ZBTB10 (rs7009110) was significantly associated with increased asthma with hay fever risk. |
---|