SNP data of: Disease - Asthma and
Biological sample - Airway Epithelial Cells
| SL. No. | Gene Name | SNP Involved | Comments | Reference (PMID) |
| 1 | ATF6B | rs2228628 | rs2228628 was significantly associated with % decline of FEV1 by aspirin provocation in asthmatics. | 24587951 |
| 2 | ATF6B | rs8111 | rs8111 was significantly associated with % decline of FEV1 by aspirin provocation in asthmatics. | 24587951 |
| 3 | DUSP1 | rs881152 | rs881152 was significantly associated with bronchodilator responsiveness in asthma patients. | 20673984 |
| 4 | DUSP1 | rs34507926 | rs34507926 genotype was significantly associated with bronchodilator responsiveness in the asthmatics. | 20673984 |
| 5 | miR-146a | rs2910164 | The CG/GG genotype of miR-146a rs2910164 was associated with higher bronchial hyperresponsiveness to methacholine compared with the CC genotype in asthmatic patients. | 28527151 |
| 6 | miR-146a | rs2910164 | The miR-146a rs2910164 polymorphism CC genotype was identified to be significantly associated with an increased risk of Bronchial hyperresponsiveness (BHR) in response to intubation in patients exhibiting basic pulmonary disease (such as asthma, emphysema and bronchitis) when compared with the GG or GC genotype. | 27431205 |
| 7 | FOXO3 | rs13217795 | This study presented the first independent verification of the association between rs13217795 and asthma. | 29141605 |
| 8 | FOXO3 | rs13217795 | An association between single nucleotide polymorphism of the FOXO3a (FOXO3) (rs13217795, C>T transition) gene and asthma in Indian population was observed in this study. | 26783460 |
| 9 | CCL5 | rs2280788 | CCL5 -28C/G (rs2280788) polymorphism is a risk factor for asthma. | 25898691 |
| 10 | TGFB1 | rs1800469 | In a dominant model, the TGFB1 rs1800469 SNP was associated with a protection against Diisocyanate induced Asthma (DA). | 25721048 |
| 11 | TGFB1 | rs2241715 | Compared with the controls, patients were found to have significantly lower frequencies of genotype AA of rs2241715. For patients with severe asthma, those with genotype AA/AG of rs2241715 had remarkably higher FEV1% as compared with those with genotype GG. | 28262390 |
| 12 | TGFB1 | rs1800469 | The -509C/T polymorphism of the TGFB1 gene might be a risk factor for asthma in the Chinese population. | 29958018 |
| 13 | TGFB1 | rs1800469 | A correlation between the C-509T SNP (rs1800469)of the TGFB1 gene and IL5 mRNA expression was demonstrated in asthmatics. | 27081784 |
| 14 | TGFB1 | rs1800469 | The polymorphism C-509T (rs1800469) may be associated with asthma and disease exacerbations. | 27627560 |
| 15 | TGFB1 | rs1800469 | TGFB1 C-509T (rs1800469) polymorphism may be risk factor for asthma. | 27717847 |
| 16 | TGFB1 | rs1982073 | TGFB1 T869C (rs1982073) polymorphism may be risk factor for asthma. | 27717847 |
| 17 | TGFB1 | rs1800470 | An association between rs1800470 (C allele) and atopic wheezing and markers of allergy was noted. A positive association was observed between the haplotype ACCA and Trichuris trichiura infection and Ascaris lumbricoides infection. This haplotype was also associated with increased IL10 production. Individuals with TGFB1 polymorphisms have an increased susceptibility to helminth infections and a lower risk of developing allergy. | 28284979 |
| 18 | TGFB1 | rs1800469 | TGFB1 C-509T (rs1800469) had the potential to modify the childhood asthma risk and the association showed no notable difference with the disease severity. | 24944803 |
| 19 | TGFB1 | rs1800469 | The T allele of C-509T (rs1800469) is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription. | 14597484 |
| 20 | TGFB1 | rs1800469 | IL4RA Q551R and TGF-beta1 C-509T are single nucleotide polymorphism loci with significant association to childhood asthma, but they do not have synergistic effects. | 19657898 |
| 21 | TGFB1 | rs1800469 | TGFbeta1 -509C>T polymorphism was not associated with the Aspirin-Intolerant Asthma (AIA) phenotype in the Korean population, but may contribute to the development of the AIA phenotype with rhinosinusitis. | 16916603 |
| 22 | TGFB1 | rs1800469 | A synergistic effect between the TGF-beta1-509C/T and IL-10-1082A/G polymorphisms on the phenotype of Aspirin-Intolerant Asthma (AIA) was noted. | 19222424 |
| 23 | MYLK | rs936170 | MYLK Polymorphism (+89872C > G) was associated with blood eosinophil level among asthmatic patients in korean population. | 19277499 |
| 24 | MYLK | 92263T >C | MYLK Polymorphism (+92263T >C) was associated with blood eosinophil level among asthmatic patients in korean population. | 19277499 |
| 25 | MYLK | rs9840993 | MYLK variant rs9840993 regulates asthmatic inflammation via alterations in mRNA secondary structure. | 25271083 |
| 26 | SPATS2L | rs295137 | rs295137 in SPATS2L was significantly associated with increased odds of Emergency department management failure in case of moderate to severe ssthma exacerbations in children. | 30644648 |
| 27 | SPATS2L | rs295137 | The minor allele of rs295137 in SPATS2L was associated with a greater acute SABA bronchodilator response in asthmatics and is more common in an African population compared to populations of European descent. | 24369795 |
| 28 | SPATS2L | rs295114 | rs295114 in SPATS2L was associated with the acute bronchodilator response to SABA in asthmatics. | 24369795 |