SNP data of: Disease - Asthma and
Biological sample - Airway Epithelial Cells
| SL. No. | Gene Name | SNP Involved | Comments | Reference (PMID) |
| 1 | SOCS1 | -1478CA > del | A significant association was noted between an SOCS1 promoter polymorphism -1478CA > del and adult asthma. | 17099141 |
| 2 | SOCS1 | rs243327 | There was a positive association in the genotype frequency of –3969C>T of the SOCS1 gene and the most severe cases of adult asthma in an allelic test. | 17099141 |
| 3 | TNF | rs1800629 | The TNFα -308 (G/A) polymorphism may be associated with increased pollutant-associated effects on FEV1 intraday variability for both SO2 and NO. The A allele may increase susceptibility to the adverse effects of air pollutants. | 27001655 |
| 4 | TNF | rs1800629 | TNF-α - 308 G/A polymorphism was significantly correlated with the risk of asthma in West Asians. | 30176222 |
| 5 | TNF | rs1799724 | TNF-α - 857C/T polymorphism was significantly correlated with the risk of asthma in Caucasians. | 30176222 |
| 6 | TNF | rs1799964 | TNF-α - 1031 T/C polymorphism was significantly correlated with the risk of asthma in Caucasians and East Asians. | 30176222 |
| 7 | TNF | rs361525 | TNF-α - 238 G/A polymorphism was significantly correlated with the risk of asthma in Caucasians. | 30176222 |
| 8 | TNF | rs1800630 | TNF-α - 863C/A polymorphism was significantly correlated with the risk of asthma in East Asians. | 30176222 |
| 9 | TNF | rs1800629 | TNFalpha -308 G/A polymorphism contributes to susceptibility to asthma. | 21082225 |
| 10 | TNF | rs1800629 | Compared to the control subjects, univariate analysis showed a significant negative association of the TNFalpha -308G>A polymorphism with atopic asthma, atopic dermatitis, asthma and skin symptoms and positive SPT. | 27240833 |
| 11 | TNF | rs1800629 | In a dominant model, TNFalpha rs1800629 SNP conferred an increased risk of Diisocyanate induced Asthma (DA). | 25721048 |
| 12 | TNF | rs1800629 | There was a strong association between the TNFalpha gene promoter polymorphism (-308G/A) and the development to asthma in both children and adults. | 31161819 |
| 13 | TNF | rs1800629 | TNFalpha -308A/G polymorphism is a risk factor for asthma. | 25668892 |
| 14 | TNF | rs1800629 | TNFalpha genetic polymorphism (-308G/A) could have a role in the development of bronchial asthma among Egyptian children. | 30600954 |
| 15 | TNF | rs1799724 | TNFalpha -857C/T polymorphism is a risk factor for asthma. | 25668892 |
| 16 | TNF | rs1800629 | The rs1800629 polymorphism in TNF-α was a risk factor for asthma. | 24936650 |
| 17 | TNF | rs1800629 | Genetic variation in TNF-α-308G/A may contribute to childhood asthma and wheezing. | 23376082 |
| 18 | TNF | rs1800630 | The TNFA-863C > A polymorphism in the promoter region of TNFA may influence TNF-alpha expression and affect TsIgE levels and susceptibility to asthma. | 16728705 |
| 19 | TNF | rs1800629 | An association between TNF-alpha G-308A (rs1800629) and asthma was noted in the North Indian population. | 16393721 |
| 20 | TNF | rs1800629 | The TNFalpha promoter polymorphism rs1800629 (-308G/A) might be associated with severe broncho hyperresponsiveness in Korean children with asthma. | 17196641 |
| 21 | TNF | rs1800629 | TNF-alpha -308A allele frequency was higher in asthmatics than in controls. | 23527710 |
| 22 | TNF | rs361525 | TNF-alpha -238A allele frequency was higher in asthmatics than in controls. | 23527710 |
| 23 | EGFR | rs4947972 | EGFR gene polymorphism (rs4947972) might be associated with presence of asymptomatic Airway Hyperresponsiveness (AHR) in young allergic adults. | 20357714 |
| 24 | EGFR | rs12718945 | EGFR gene polymorphism (rs12718945) might be associated with presence of asymptomatic Airway Hyperresponsiveness (AHR) in young allergic adults. | 20357714 |
| 25 | EGFR | rs2227983 | EGFR gene polymorphism (rs2227983) might be associated with presence of asymptomatic Airway Hyperresponsiveness (AHR) in young allergic adults. | 20357714 |
| 26 | EGFR | rs2072454 | EGFR gene polymorphism (rs2072454) might be associated with presence of asymptomatic Airway Hyperresponsiveness (AHR) in young allergic adults. | 20357714 |
| 27 | EGFR | rs2293347 | EGFR gene polymorphism (rs2293347) might be associated with presence of asymptomatic Airway Hyperresponsiveness (AHR) in young allergic adults. | 20357714 |
| 28 | SOCS3 | rs9914220 | The polymorphism of the SOCS3 gene rs9914220 site is correlated with the onset of childhood asthma. | 31539147 |
| 29 | SOCS3 | rs4969170 | Compared with GG/GA genotype in SOCS3 rs4969170, AA genotype obviously increased the susceptibility to asthma in children. | 26464723 |
| 30 | SOCS3 | rs4969168 | Differently in rs4969168, AG and AG/GG genotypes distributions had significant differences in the asthma patient and control groups. | 26464723 |
| 31 | SPP1 | rs1126616 | Haplotype analysis identified rs1126616C-rs1126772A-rs9138A to be associated with an increased risk for asthma, severity of asthma and asthma in subjects with elevated IgE. | 22276228 |
| 32 | SPP1 | rs9138 | Haplotype analysis identified rs1126616C-rs1126772A-rs9138A to be associated with an increased risk for asthma, severity of asthma and asthma in subjects with elevated IgE. | 22276228 |
| 33 | SPP1 | rs1126772 | Haplotype analysis identified rs1126616C-rs1126772A-rs9138A to be associated with an increased risk for asthma, severity of asthma and asthma in subjects with elevated IgE. | 22276228 |
| 34 | ITGB8 | rs6461503 | rs6461503 was associated with asthma and allergic diseases. | 29785011 |
| 35 | FBXL7 | rs10044254 | rs10044254 was associated with both decreased expression of FBXL7 and improved symptomatic response to Inhaled Corticosteroids in 2 independent pediatric asthma cohorts. | 24486069 |
| 36 | TLR2 | rs4696480 | TLR2 rs4696480 polymorphism is significantly associated with asthma susceptibility and the TLR2 rs4696480 polymorphism is a risk factor for asthma. | 28514297 |
| 37 | TLR2 | rs3804099 | rs3804099 of TLR2 was significantly associated with asthma risk. | 28858111 |
| 38 | TLR2 | rs3804099 | The TLR2 +596C/T SNP was found to be significantly associated to asthma particularly to females. | 27495363 |
| 39 | TLR2 | rs3804100 | Both Type 1 Diabetes and allergic asthma were significantly associated with the TLR2 rs3804100 T allele and further associated with the haplotype including this SNP, possibly representing a susceptibility locus common for the two diseases. | 19148143 |
| 40 | TLR2 | rs5743708 | TLR2 Arg753Gln (rs5743708) might contribute significantly to asthma susceptibility. | 25729620 |
| 41 | ORMDL3 | rs11650680 | In rs11650680 of ORMDL3 gene the CT genotype is more prevalent in female asthma cases in comparison with female controls. | 29588858 |
| 42 | ORMDL3 | rs8076131 | The 17q12-21 locus has a strong genetic association with Allergic Asthma but not with Allergic Rhinitis. The polymorphic effect of this locus is attributed to the linkage set tagged by rs8076131, which affects the expression of ORMDL3, PPP1R1B, ZPBP2 and GSDMB and is correlated with high IgE levels and eosinophil counts in subjects bearing the risk genotype. | 26483175 |
| 43 | ORMDL3 | rs8076131 | rs8076131 was suggestive of case control status considering the major allele in a dominant model. This SNP was associated with asthma. | 28668238 |
| 44 | ORMDL3 | rs4065275 | The asthma-risk variants rs4065275 and rs12936231 switched CTCF-binding sites in the 17q21 locus and 4C-Seq assays showed that several distal cis-regulatory elements upstream of the disrupted ZPBP2 CTCF-binding site interacted with the ORMDL3 promoter region in CD4+ T cells exclusively from subjects carrying asthma-risk alleles. | 27848966 |
| 45 | ORMDL3 | rs4795405 | rs4795405 was significantly associated with asthma. | 27439200 |
| 46 | ORMDL3 | rs12603332 | The risk allele (C allele) for rs12603332 was found to be significantly associated with male asthma patients residing in urban localities of Lahore. | 28055272 |
| 47 | ORMDL3 | rs7216389 | rs7216389 was significantly associated with increased asthma risk in overall population. Children with variant T allele (TT or TC) and adults with TT homozygote in rs7216389 are at high risks to suffer from asthma. | 26064206 |
| 48 | ORMDL3 | rs11650680 | People with T allele in rs11650680 are protected from asthma. | 26064206 |
| 49 | ORMDL3 | rs12603332 | People with T allele in rs12603332 are protected from asthma. | 26064206 |
| 50 | ORMDL3 | rs7216389 | The ORMDL3 gene influences childhood asthma and the TT genotype of the rs7216389 polymorphism is associated with childhood asthma in the Chinese population. | 23096927 |
| 51 | IL1A | rs17561 | Gain-of-function IL1A rs17561 resulted significantly associated with a reduced pulmonary capacity in asthmatic children. | 29154202 |
| 52 | IL1A | rs17561 | The distribution of the IL1A genotype (G4845T) differed significantly between asthmatics with and without nasal polyposis. The risk of nasal polyposis was markedly increased in allele G homozygous subjects. | 12752325 |
| 53 | IL1A | rs1800587 | IL-1alpha -889C/C homozygous condition was significantly associated with asthma. | 23527710 |
| 54 | IL6R | rs2228145 | An increased risk of atopic asthma compared to non-atopic asthma per copy of the minor allele of rs2228145. There was a positive association between the Asp358Ala variant and atopic asthma. Enhanced shedding of sIL-6R from neutrophils of Asp358Ala homozygotes and an increase in the MCP1 release from lung endothelial cells provides evidence of a mechanism through which IL-6 trans-signaling may contribute to disease severity in severe, neutrophil-driven, asthma phenotypes. | 28334838 |
| 55 | IL6R | rs2228145 | rs2228145 C is associated with poor lung function in patients with asthma. The rs2228145 A-C variant is associated with levels of sIL-6R and IgE. | 26997259 |
| 56 | IL6R | rs12083537 | rs12083537 G is associated with poor lung function in patients with asthma. | 26997259 |
| 57 | IL6R | rs2228145 | The IL6R coding SNP rs2228145 (Asp(358)Ala) is a potential modifier of lung function in subjects with asthma and might identify subjects at risk for more severe asthma. | 22554704 |
| 58 | IL6R | rs12083537 | rs12083537:A allele increased asthma risk by 1.04-fold. | 23945879 |