SNP data of: Disease - Asthma and
Biological sample - Blood
| SL. No. | Gene Name | SNP Involved | Comments | Reference (PMID) |
| 1 | GATA3 | rs10795656 | rs10795656 was associated with asthma and allergic diseases. | 29785011 |
| 2 | GATA3 | rs422628 | cg17124583 modified the association of SNP rs422628 with asthma risk at the age of 18 years. Subjects with genotype AG showed an increase in average risk ratio from 0.31 to 11.65 when methylation level increased from 0.02 to 0.12, relative to genotype AA | 25250096 |
| 3 | GATA3 | rs1269486 | The interaction between Oral Contraceptive Pill (OCP) use and SNP rs1269486 was found to be associated with the methylation level of cg17124583 in asthma. | 25250096 |
| 4 | STAT1 | rs3771300 | The polymorphism C39134A (rs3771300), located in a potentially cis acting regulatory element in STAT1 intron 24, was inversely related to atopy measured by skin prick test, total and specific serum IgE levels. STAT1 SNP C39134A may protect from atopic sensitization. | 17983380 |
| 5 | STAT3 | G3363a16 | G3363a16 was significantly associated with baseline FEV1: homozygotes for the minor allele of the polymorphism had lower FEV1 than homozygotes for the major alleles. | 15935090 |
| 6 | STAT3 | rs1026916 | rs1026916 was significantly associated with baseline FEV1: homozygotes for the minor allele of the polymorphism had lower FEV1 than homozygotes for the major alleles. | 15935090 |
| 7 | STAT3 | rs957971 | rs957971 was significantly associated with baseline FEV1: homozygotes for the minor allele of the polymorphism had lower FEV1 than homozygotes for the major alleles. | 15935090 |
| 8 | STAT3 | rs2293452 | A significant association between STAT3 polymorphism (rs2293452) and asthma susceptibility in atopic asthma. Polymorphism of STAT3 (rs2293452) may be useful as a new DNA-based diagnostic biomarker for identifying high-risk children susceptible to asthma. | 21624746 |
| 9 | JAK2 | rs3780375 | rs3780375 in the JAK2 gene was associated with number of illnesses and cold symptom burden in RhinoGen study and with asthma at age 6 years and all three wheezing phenotypes in COAST (Childhood Origins of Asthma) study. | 26399222 |
| 10 | TGFB1 | rs1800469 | In a dominant model, the TGFB1 rs1800469 SNP was associated with a protection against Diisocyanate induced Asthma (DA). | 25721048 |
| 11 | TGFB1 | rs2241715 | Compared with the controls, patients were found to have significantly lower frequencies of genotype AA of rs2241715. For patients with severe asthma, those with genotype AA/AG of rs2241715 had remarkably higher FEV1% as compared with those with genotype GG. | 28262390 |
| 12 | TGFB1 | rs1800469 | The -509C/T polymorphism of the TGFB1 gene might be a risk factor for asthma in the Chinese population. | 29958018 |
| 13 | TGFB1 | rs1800469 | A correlation between the C-509T SNP (rs1800469)of the TGFB1 gene and IL5 mRNA expression was demonstrated in asthmatics. | 27081784 |
| 14 | TGFB1 | rs1800469 | The polymorphism C-509T (rs1800469) may be associated with asthma and disease exacerbations. | 27627560 |
| 15 | TGFB1 | rs1800469 | TGFB1 C-509T (rs1800469) polymorphism may be risk factor for asthma. | 27717847 |
| 16 | TGFB1 | rs1982073 | TGFB1 T869C (rs1982073) polymorphism may be risk factor for asthma. | 27717847 |
| 17 | TGFB1 | rs1800470 | An association between rs1800470 (C allele) and atopic wheezing and markers of allergy was noted. A positive association was observed between the haplotype ACCA and Trichuris trichiura infection and Ascaris lumbricoides infection. This haplotype was also associated with increased IL10 production. Individuals with TGFB1 polymorphisms have an increased susceptibility to helminth infections and a lower risk of developing allergy. | 28284979 |
| 18 | TGFB1 | rs1800469 | TGFB1 C-509T (rs1800469) had the potential to modify the childhood asthma risk and the association showed no notable difference with the disease severity. | 24944803 |
| 19 | TGFB1 | rs1800469 | The T allele of C-509T (rs1800469) is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription. | 14597484 |
| 20 | TGFB1 | rs1800469 | IL4RA Q551R and TGF-beta1 C-509T are single nucleotide polymorphism loci with significant association to childhood asthma, but they do not have synergistic effects. | 19657898 |
| 21 | TGFB1 | rs1800469 | TGFbeta1 -509C>T polymorphism was not associated with the Aspirin-Intolerant Asthma (AIA) phenotype in the Korean population, but may contribute to the development of the AIA phenotype with rhinosinusitis. | 16916603 |
| 22 | TGFB1 | rs1800469 | A synergistic effect between the TGF-beta1-509C/T and IL-10-1082A/G polymorphisms on the phenotype of Aspirin-Intolerant Asthma (AIA) was noted. | 19222424 |
| 23 | TSLP | rs1837253 | rs1837253 was found to be associated with asthma. | 28461288 |
| 24 | TSLP | rs17132582 | rs17132582 is an eQTL for TSLP gene which is significantly associated with asthma risk. | 27554816 |
| 25 | TSLP | rs1837253 | rs1837253 was associated with asthma and allergic diseases. | 29785011 |
| 26 | TSLP | rs1837253 | The rs1837253:C allele was associated with increased asthma with hay fever risk. | 24388013 |
| 27 | TSLP | rs3806933 | The promoter polymorphism rs3806933 was significantly associated with disease susceptibility in both childhood atopic and adult asthma. | 20656951 |
| 28 | TSLP | rs2289276 | The promoter polymorphism rs2289276 was significantly associated with disease susceptibility in both childhood atopic and adult asthma. | 20656951 |
| 29 | TNFSF10 | rs12488654 | Combinations of SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) in the TNFSF10 allele were strongly associated with asthma. | 20961336 |
| 30 | TNFSF10 | rs3136586 | Combinations of SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) in the TNFSF10 allele were strongly associated with asthma. | 20961336 |
| 31 | TNFSF10 | rs3136604 | Combinations of SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) in the TNFSF10 allele were strongly associated with asthma. | 20961336 |
| 32 | TNFSF10 | rs3136598 | Combinations of SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) in the TNFSF10 allele were strongly associated with asthma. | 20961336 |
| 33 | OXA1L | rs4981436 | Significant association between C allele of OXA1L SNP rs4981436 and asthma was noted in South American population. | 30032071 |
| 34 | OXA1L | rs17619 | Significant association between A allele of OXA1L SNP rs17619 and production of IFNG stimulated with Blomia tropicalis was noted in South American population. | 30032071 |
| 35 | OXA1L | rs8572 | Significant association between G allele of OXA1L SNP rs8572 with positive skin prick test for dog epithelium, Periplanata americana, Dermatophagoides pteronyssinus and specific IgE for Dermatophagoides pteronyssinus was noted in South American population. | 30032071 |
| 36 | CCL5 | rs2280788 | CCL5 -28C/G (rs2280788) polymorphism is a risk factor for asthma. | 25898691 |
| 37 | CXCL8 | rs4073 | rs4073 was significantly associated with an increased risk of asthma. The rs4073 T allele was a risk factor for asthma development. The rs4073 T allele is represented as a risk factor for asthma severity in Tunisian children. | 28993876 |
| 38 | CXCL8 | rs2227306 | rs2227306 was significantly associated with an increased risk of asthma. The rs2227306 C allele was a risk factor for asthma development. | 28993876 |
| 39 | CXCL8 | C1633T | CXCL8 (IL8) C1633T polymorphism was associated with asthma. | 15356575 |
| 40 | CXCL8 | A2767T | CXCL8 (IL8) A2767T polymorphism was associated with asthma. | 15356575 |
| 41 | CXCL8 | rs2227306 | CXCL8 (IL8) C781T (rs2227306) polymorphism was associated with asthma. | 15356575 |
| 42 | CXCL8 | rs4073 | CXCL8 (IL8) -A251T (rs4073) was associated with asthma, which is the opposite allele as described in association with RSV bronchiolitis. | 15356575 |
| 43 | CXCL8 | rs2227306 | The IL8 (CXCL8) polymorphism -781C/T as well as IL8 haplotypes were associated with asthma. | 16503988 |
| 44 | IL6 | rs1800797 | The GG genotype of rs1800797 is associated with increased risk of asthma among those who had some tobacco smoke exposure. This GG genotype may increase susceptibility to the adverse effects of smoking on the risk of asthma. | 28987812 |
| 45 | IL6 | rs1800795 | The GG genotype of rs1800795 is associated with increased risk of asthma among those who had some tobacco smoke exposure. This GG genotype may increase susceptibility to the adverse effects of smoking on the risk of asthma. | 28987812 |
| 46 | IL6 | rs1800795 | Polymorphism of C174G gene of interleukin-6 (IL6) are associated with higher activity of inflammation and therefore with increased risk of occupational bronchial asthma associated with metabolic syndrome and diabetess mellitus 2 type. | 30351648 |
| 47 | IL6 | rs1800795 | A significant association was noted between IL6 polymorphism at -174G/C (rs1800795) and bronchial asthma. Higher associations between polymorphism at IL-6 -174G/C and bronchial asthma were observed in atopic patients. | 28185773 |
| 48 | IL6 | rs1800797 | IL6 SNP rs1800797 is associated with the risk of adult-onset asthma. | 26938664 |
| 49 | IL6 | rs1800795 | IL6 -174 CC genotype may be a protective factor against asthma in Caucasian and adults. | 26550171 |
| 50 | IL6 | rs1800795 | IL6 (rs1800795) polymorphisms can be considered as genetic marker for bronchial asthma susceptibility and severity among Egyptian children. | 18810365 |
| 51 | IL10 | rs1800896 | IL10 -1082G/A polymorphism might be a risk factor for asthma in children. A significant association between this polymorphism in Asian populations and pediatric asthma in a dominant model and non-Asian populations and pediatric asthma in a recessive model. -1082G/A polymorphism was significantly associated with non-atopic asthma in children in the additive and allelic models and with atopic asthma in children in the recessive model. | 27323141 |
| 52 | IL10 | rs1800896 | IL10 rs1800896 gene polymorphism was associated with post-bronchiolitis asthma at 11-13 years of age in children hospitalised for bronchiolitis at less than six months of age. | 31074014 |
| 53 | IL10 | rs1800896 | A significant association was observed between the IL10 polymorphism (-1082G/A) and asthma in both atopic and non-atopic asthma groups. | 21624746 |
| 54 | IL10 | rs1800871 | An association was observed between IL10 rs1800871 and mild asthma. | 26108303 |
| 55 | IL10 | rs1800896 | IL10 rs1800896 SNP was significantly associated with preschool asthma after severe lower respiratory tract infection in early infancy. | 24167151 |
| 56 | IL10 | rs1800896 | An association was observed between IL10 rs1800896 and mild asthma. | 26108303 |
| 57 | IL10 | rs1800896 | A suggestive evidence of association was obtained for -1082 A/G polymorphism at the level of alleles and genotypes with asthma. | 16008678 |
| 58 | IL10 | rs1800896 | AG or GG genotype of IL-10-1082A/G was significantly higher in the patients with Aspirin-Intolerant Asthma (AIA). | 19222424 |
| 59 | IL10 | rs1800896 | IL10 promoter -1028A/G (rs1800896), -592A/C (rs1800872) polymorphisms and their haplotypes correlate with asthma susceptibility. | 24162871 |
| 60 | IL10 | rs1800872 | IL10 promoter -1028A/G (rs1800896), -592A/C (rs1800872) polymorphisms and their haplotypes correlate with asthma susceptibility | 24162871 |
| 61 | IL10 | rs1800896 | The -1082A>G polymorphism and ATA haplotype in the IL-10 promoter gene were associated with airway hyper responsiveness (AHR) in asthmatics. | 21779975 |
| 62 | IL10 | rs1800896 | IL-10 -1082G/A heterozygous condition was significantly associated with asthma. | 23527710 |
| 63 | IL10 | rs1800896 | Significant association between -1082A/G polymorphism and asthma was observed. | 23017230 |
| 64 | IL10 | rs1800871 | The CC genotype of IL10 T-819C compared to the TT genotype may have a protective effect on asthma risk in younger adults (25-40 years old), and males in Taiwan. | 26546526 |
| 65 | IL10 | rs1800872 | IL10 -592A>C showed multiple associations with allergic sensitization and asthma phenotypes. | 29314322 |
| 66 | IL10 | rs1800896 | IL10 -1082A>G showed multiple associations with allergic sensitization and asthma phenotypes. | 29314322 |
| 67 | IL10 | rs1800872 | Significant association between -592A/C polymorphism and asthma was observed. | 23017230 |
| 68 | ADCY9 | rs2601796 | rs2601796 was positively associated with asthma. rs2601796 was significantly associated with skin prick test for Dermatophagoides pteronyssinus. | 28076799 |
| 69 | ADCY9 | rs2601814 | rs2601814 was positively associated with asthma. rs2601814 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus or atleast one of the allergen tested. | 28076799 |
| 70 | ADCY9 | rs2283497 | rs2283497 was negatively associated with allergy in asthmatic patients. rs2283497 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus or atleast one of the allergen tested. rs2283497 was significantly associated with sIgE for Blomia tropicalis and Dermatophagoides pteronyssinus. | 28076799 |
| 71 | ADCY9 | rs8061182 | rs8061182 was positively associated with allergy in asthmatic patients. rs8061182 was significantly associated with skin prick test for Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested. | 28076799 |
| 72 | ADCY9 | rs4785947 | rs4785947 was positively associated with allergy in asthmatic patients. rs4785947 was significantly associated with sIgE for Blomia tropicalis. | 28076799 |
| 73 | ADCY9 | kgp12201986 | kgp12201986 was positively associated with allergy in asthmatic patients. kgp12201986 was significantly associated with skin prick test for Periplaneta americana, Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested. kgp12201986 was also significantly associated sIgE for Blomia tropicalis or atleast one of the allergen tested. | 28076799 |
| 74 | IL13 | rs1881457 | rs1881457 in IL13 was correlated with the expression levels of IL13 and the expression levels of IL13 was correlated with asthma in BAL and thus, IL13 is more likely to be the functional asthma gene in the region. | 27050946 |
| 75 | IL13 | rs20541 | rs20541 is associated with asthma. | 27050946 |
| 76 | IL13 | rs20541 | IL13 minor A allele for rs20541 was associated with significantly higher risk of asthma in the Saudi Arabian population. | 29211635 |
| 77 | IL13 | rs1295686 | IL13 minor T allele for rs1295686 was associated with significantly higher risk of asthma in the Saudi Arabian population. | 29211635 |
| 78 | IL13 | rs20541 | Individuals homozygous for the risk alleles (GG) for rs20541 are at a higher risk for developing asthma compared with those without any risk homozygotes. IL13 rs20541 (G allele), IL4 rs2243250 (T allele), ADRB2 rs1042713 (A allele), and FCER1B rs569108 (G allele), four SNPs with significant sole effect on asthma, interact to confer a higher risk for the disease in Chinese Han children. | 26613553 |
| 79 | IL13 | rs1295686 | IL13 rs1295686 was associated with all asthma and early-onset asthma in adults. Moreover, SLC22A5, IL13, SMAD3, and GSDMB interact to modulate spirometric indices. | 26534891 |
| 80 | IL13 | rs20541 | The IL13 +2044G/A polymorphism is a risk factor for asthma, especially among Asians. | 29390465 |
| 81 | IL13 | rs1295686 | The IL13 +1923C/T polymorphism is a risk factor for asthma, especially among Asians. | 29390465 |
| 82 | IL13 | rs20541 | Significant correlation was found between rs20541 in IL13 gene and the positive skin prick test results. | 26426602 |
| 83 | IL13 | rs20541 | IL13 AA of rs20541 is a potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling. | 26765219 |
| 84 | IL13 | rs20541 | IL13 rs20541 GG genotype was associated with less susceptibility to asthma. | 27561723 |
| 85 | IL13 | G4257A | The 4257GA heterozygous and 4257AA homozygous mutant alleles were associated with higher IL-13 production in asthmatics. | 23865080 |
| 86 | IL13 | rs1295686 | IL13 +1923C/T (rs1295686) polymorphism was a risk factor for asthma susceptibility, especially in Asians and Caucasians. | 28057889 |
| 87 | IL13 | rs1881457 | rs1881457 (A-1512C) polymorphism in IL13 is a risk factor for asthma and Allergic rhinitis. | 23996716 |
| 88 | IL13 | rs1800925 | The -1111T mutant allele (rs1800925) are associated with asthma. | 23865080 |
| 89 | IL13 | rs848 | rs848 in the IL13 gene region is significantly associated with a continuous measure of symptom severity in adult subjects with ever asthma. | 26986948 |
| 90 | IL13 | rs20541 | IL13 Arg130Gln (rs20541) gene polymorphisms is associated with the asthma susceptibility and increased serum total IgE in Uygur children in Xinjiang. The A/A genotype frequency and A allele frequency of Arg130Gln locus in IL13 in the asthma group were obviously higher than those in the control group. | 30680016 |
| 91 | IL13 | rs20541 | IL13 rs20541 was associated with the Asthma Predictive Index (API) and atopy. | 29761786 |
| 92 | IL13 | rs1295686 | IL13 C1923T (rs1295686) TT has been detected to be the susceptible genotype and may have a significant effect on the pathogenesis of childhood asthma in the Mauritian population. | 26155367 |
| 93 | IL13 | rs20541 | The SNP rs20541 in IL13 was associated with airway hyperresponsiveness in Japanese adult asthmatics. | 23978640 |
| 94 | IL13 | rs848 | SNP rs848 in the IL13 gene region was associated with symptom and treatment score (STS) in asthmatics. | 26986948 |
| 95 | IL13 | rs1800925 | IL13 C-1112T makes little contribution to the development of asthma in children of Chinese Han nationality. | 19862939 |
| 96 | IL13 | rs1295686 | IL13 C1923T makes little contribution to the development of asthma in children of Chinese Han nationality. | 19862939 |
| 97 | IL13 | rs1295686 | The IL13 C1923T locus predisposed to asthma in Mauritian Indian children. | 24838642 |
| 98 | IL13 | rs1881457 | IL13 SNP rs1881457(-1512) was associated with atopy risk. rs1881457(-1512) was associated with better FEV(1) and FEV(1)/FVC in asthmatics. | 19796199 |
| 99 | IL13 | rs1800925 | IL13 SNP rs1800925 was associated with atopy risk. rs1800925 was associated with better FEV(1) and FEV(1)/FVC in asthmatics. | 19796199 |
| 100 | IL13 | rs20541 | IL13 rs20541 was significantly associated with self-reported asthma and allergy. | 19254294 |
| 101 | IL13 | rs1800925 | IL13 rs1800925 was significantly associated with self-reported asthma and allergy. | 19254294 |