SNP data of: Disease - Asthma and
Biological sample - CD4 T Cells
| SL. No. | Gene Name | SNP Involved | Comments | Reference (PMID) |
| 1 | STAT1 | rs3771300 | The polymorphism C39134A (rs3771300), located in a potentially cis acting regulatory element in STAT1 intron 24, was inversely related to atopy measured by skin prick test, total and specific serum IgE levels. STAT1 SNP C39134A may protect from atopic sensitization. | 17983380 |
| 2 | STAT6 | GT polymorphism | S allele (GT13 and GT14) of the GT repeat polymorphism confers significant risks to asthma. | 23861779 |
| 3 | STAT6 | rs71802646 | Short GT repeats of rs71802646 in STAT6 contribute to higher risk for asthma. | 24952213 |
| 4 | STAT6 | rs324015 | rs324015 may have a protective effect on atopic asthma. | 24952213 |
| 5 | STAT6 | rs1059513 | rs1059513 was associated with asthma and allergic diseases. | 29785011 |
| 6 | STAT6 | rs3024974 | STAT6 C1570T polymorphism may influence lung function growth in asthmatic children. | 17883727 |
| 7 | RUNX3 | rs742230 | rs742230 was associated with asthma and allergic diseases. | 29785011 |
| 8 | GATA3 | rs10795656 | rs10795656 was associated with asthma and allergic diseases. | 29785011 |
| 9 | GATA3 | rs422628 | cg17124583 modified the association of SNP rs422628 with asthma risk at the age of 18 years. Subjects with genotype AG showed an increase in average risk ratio from 0.31 to 11.65 when methylation level increased from 0.02 to 0.12, relative to genotype AA | 25250096 |
| 10 | GATA3 | rs1269486 | The interaction between Oral Contraceptive Pill (OCP) use and SNP rs1269486 was found to be associated with the methylation level of cg17124583 in asthma. | 25250096 |
| 11 | ZBTB10 | rs2136016 | rs2136016 was associated with asthma and allergic diseases. | 29785011 |
| 12 | ZBTB10 | rs7009110 | ZBTB10 (rs7009110) was significantly associated with increased asthma with hay fever risk. | 24388013 |
| 13 | ATF3 | rs72756369 | rs72756369, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. | 29969634 |
| 14 | ATF3 | rs11571537 | rs11571537, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. | 29969634 |
| 15 | ATF3 | rs11571559 | rs11571559, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. | 29969634 |
| 16 | NFKB1 | rs28450894 | The T allele of rs28450894 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. The low BDR associated T allele of NFKB1 (rs28450894) is found predominantly among African populations. The low BDR associated T allele of rs28450894 is significantly associated with decreased expression of SLC39A8 in blood. | 29509491 |
| 17 | NFKB1 | rs4648006 | The T allele of rs4648006 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. | 29509491 |
| 18 | IFNG | rs2430561 | The allelic frequencies of the AA genotypes in IFNG at +874 is associated with an increased risk of asthma in the Chinese Han adult population. | 24995662 |
| 19 | IFNG | CA repeat polymorphism | IFNG CA repeat polymorphism confer genetic susceptibility to atopic asthma in Japanese children. | 11240951 |
| 20 | IFNG | CA repeat polymorphism | CA14 occurrence in the first intron of IFNG can increase the risk of asthma in the Japanese population. | 24995662 |
| 21 | IFNG | rs1861494 | rs1861494 A/G polymorphism was associated with asthma, which may regulate the IFNgamma levels and, hence, modulate asthma pathogenesis. | 18385742 |
| 22 | TNF | rs1800629 | The TNFα -308 (G/A) polymorphism may be associated with increased pollutant-associated effects on FEV1 intraday variability for both SO2 and NO. The A allele may increase susceptibility to the adverse effects of air pollutants. | 27001655 |
| 23 | TNF | rs1800629 | TNF-α - 308 G/A polymorphism was significantly correlated with the risk of asthma in West Asians. | 30176222 |
| 24 | TNF | rs1799724 | TNF-α - 857C/T polymorphism was significantly correlated with the risk of asthma in Caucasians. | 30176222 |
| 25 | TNF | rs1799964 | TNF-α - 1031 T/C polymorphism was significantly correlated with the risk of asthma in Caucasians and East Asians. | 30176222 |
| 26 | TNF | rs361525 | TNF-α - 238 G/A polymorphism was significantly correlated with the risk of asthma in Caucasians. | 30176222 |
| 27 | TNF | rs1800630 | TNF-α - 863C/A polymorphism was significantly correlated with the risk of asthma in East Asians. | 30176222 |
| 28 | TNF | rs1800629 | TNFalpha -308 G/A polymorphism contributes to susceptibility to asthma. | 21082225 |
| 29 | TNF | rs1800629 | Compared to the control subjects, univariate analysis showed a significant negative association of the TNFalpha -308G>A polymorphism with atopic asthma, atopic dermatitis, asthma and skin symptoms and positive SPT. | 27240833 |
| 30 | TNF | rs1800629 | In a dominant model, TNFalpha rs1800629 SNP conferred an increased risk of Diisocyanate induced Asthma (DA). | 25721048 |
| 31 | TNF | rs1800629 | There was a strong association between the TNFalpha gene promoter polymorphism (-308G/A) and the development to asthma in both children and adults. | 31161819 |
| 32 | TNF | rs1800629 | TNFalpha -308A/G polymorphism is a risk factor for asthma. | 25668892 |
| 33 | TNF | rs1800629 | TNFalpha genetic polymorphism (-308G/A) could have a role in the development of bronchial asthma among Egyptian children. | 30600954 |
| 34 | TNF | rs1799724 | TNFalpha -857C/T polymorphism is a risk factor for asthma. | 25668892 |
| 35 | TNF | rs1800629 | The rs1800629 polymorphism in TNF-α was a risk factor for asthma. | 24936650 |
| 36 | TNF | rs1800629 | Genetic variation in TNF-α-308G/A may contribute to childhood asthma and wheezing. | 23376082 |
| 37 | TNF | rs1800630 | The TNFA-863C > A polymorphism in the promoter region of TNFA may influence TNF-alpha expression and affect TsIgE levels and susceptibility to asthma. | 16728705 |
| 38 | TNF | rs1800629 | An association between TNF-alpha G-308A (rs1800629) and asthma was noted in the North Indian population. | 16393721 |
| 39 | TNF | rs1800629 | The TNFalpha promoter polymorphism rs1800629 (-308G/A) might be associated with severe broncho hyperresponsiveness in Korean children with asthma. | 17196641 |
| 40 | TNF | rs1800629 | TNF-alpha -308A allele frequency was higher in asthmatics than in controls. | 23527710 |
| 41 | TNF | rs361525 | TNF-alpha -238A allele frequency was higher in asthmatics than in controls. | 23527710 |
| 42 | FOXP3 | rs56066773 | The mutated allele of 7340C>T was significantly associated with the simultaneous presence of autoimmunity and atopy in male children. | 25982578 |
| 43 | FOXP3 | rs2232367 | A significant increase in the frequency of the mutated allele of 1651C>T in the male control group as compared to patients with atopy and autoimmunity. | 25982578 |