SNP data of: Disease - Allergic Rhinitis (AR) and Biological sample - Nasal Tissues

SL. No.Gene Name SNP InvolvedCommentsReference (PMID)
1STAT1rs3771300The polymorphism C39134A (rs3771300), located in a potentially cis acting regulatory element in STAT1 intron 24, was inversely related to atopy measured by skin prick test, total and specific serum IgE levels. STAT1 SNP C39134A may protect from atopic sensitization.17983380
2GATA3rs1269486The SNP at rs1269486 of GATA3 is associated with allergic rhinitis in Chinese.18826115
3GATA3rs1269486 The frequency of the G allele of rs1269486 in the allergic rhinitis patient group was significantly higher than that in the control group, while the frequency of the A allele in the patient group was significantly lower than that in the control group. 18607915
4GATA3rs2229360The haplotype frequency of GC at the two loci (rs1269486 and rs2229360) in the allergic rhinitis patient group was significantly higher than that in the control group, and the haplotype frequency of AC in the patient group was significantly lower than that in the control group.18607915
5TGFB1rs1800469TGFB1 gene polymorphism -509C/T may play a potential role in the severity of persistent Allergic Rhinitis in childhood.21055322
6TGFB1rs747857rs747857 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
7TGFB1rs6508975rs6508975 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
8TGFB1rs2241715rs2241715 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
9TGFB1rs12462166rs12462166 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
10TGFB1rs12983775rs12983775 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
11TGFB1rs1800470rs1800470 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
12TGFB1rs2317130rs2317130 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
13TGFB1rs11466359rs11466359 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
14TGFB1rs12461895 rs12461895 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
15TGFB1rs7258445rs7258445 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
16TGFB1rs11466345rs11466345 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
17TGFB1rs2241717rs2241717 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.26791767
18TGFB1rs1800471The C allele and the CG genotype in rs1800471 in TGFB1 were associated with a higher susceptibility to Allergic Rhinitis.26316419
19TGFB1rs1982037C/C and T/C haplotypes (rs1982037, rs1800471) in TGFB1 gene were found with higher frequencies in allergic rhinitis patients than controls.26316419
20TGFB1rs1800469Polymorphism -509C/T (rs1800469) in TGFB1 promoter is associated with increased risk and severity of persistent Allergic Rhinitis in Chinese Population.32216462
21OXA1Lrs17619Significant association between A allele of OXA1L SNP rs17619 and production of IFNG stimulated with Blomia tropicalis was noted in South American population.30032071
22OXA1Lrs8572Significant association between G allele of OXA1L SNP rs8572 with positive skin prick test for dog epithelium, Periplanata americana, Dermatophagoides pteronyssinus and specific IgE for Dermatophagoides pteronyssinus was noted in South American population.30032071
23TSLPrs1898671TSLP rs1898671 polymorphism was associated with a higher risk for allergic rhinitis.26629072
24CCL5rs2107538The frequency of RANTES -403A (rs2107538) allele was significantly higher in patients with allergic rhinitis than in control subjects.15064621
25CCL5rs2280788The frequency of RANTES -28G (rs2280788) allele was significantly higher in patients with allergic rhinitis than in control subjects.15064621
26IL6rs1800795Patients homozygous for the G allele of rs1800795 in IL6 had a 3.35 fold risk of having Allergic Rhinitis than those with the C allele.24974143
27IL6rs1800797AA genotype in rs1800797 of IL6 was associated with the increased risk of developing Allergic Rhinitis.24974143
28IL6rs1800795IL6 rs1800795 polymorphism was associated with an increased risk of allergic rhinitis.26909898
29IL10rs1800896A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL10 gene were found with higher frequencies in allergic rhinitis patients than controls.26316419
30IL10rs1800872A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL10 gene were found with higher frequencies in allergic rhinitis patients than controls.26316419
31IL10rs1800871A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL10 gene were found with higher frequencies in allergic rhinitis patients than controls. Patients with CC genotype in rs1800871 in IL10 had significantly lower levels of IgE.26316419
32IL13rs20541IL13 polymorphism (rs20541, Exo 4, G>A, Arg130Gln) and IL4 polymorphism (rs2243250= C-590T, promoter, T>C) are co-associated with Allergic Rhinitis and sensitivity to aeroallergens.31832433
33IL13rs1881457rs1881457 (A-1512C) polymorphism in IL13 is a risk factor for asthma and Allergic rhinitis.23996716
34IL13rs20541Polymorphic variant of IL13 R130Q appears to be associated with increased risk for development of allergic rhinitis in a hospital-based Malaysian22852128
35IL13rs20541The IL13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans.17091279
36IL13rs20541IL13 SNP rs20541 was associated with Allergic Rhinitis, particularly in Asians23545317
37IL13rs20541IL13 SNP rs20541 (Arg > Gln) was significantly associated with Allergic Rhinitis.23954258
38IL13rs20541There is evidence for an overall association between IL13 SNP rs20541 and increased risk of Allergic Rhinitis.21309855
39ADCY9rs2601796rs2601796 was significantly associated with skin prick test for Dermatophagoides pteronyssinus.28076799
40ADCY9rs2601814rs2601814 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus or atleast one of the allergen tested.28076799
41ADCY9rs2283497rs2283497 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus or atleast one of the allergen tested. rs2283497 was significantly associated with sIgE for Blomia tropicalis and Dermatophagoides pteronyssinus.28076799
42ADCY9rs8061182rs8061182 was significantly associated with skin prick test for Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested.28076799
43ADCY9rs4785947rs4785947 was positively associated with allergy in asthmatic patients. rs4785947 was significantly associated with sIgE for Blomia tropicalis.28076799
44ADCY9kgp12201986kgp12201986 was positively associated with allergy in asthmatic patients. kgp12201986 was significantly associated with skin prick test for Periplaneta americana, Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested. kgp12201986 was also significantly associated sIgE for Blomia tropicalis or atleast one of the allergen tested.28076799
45ADCY9rs432166rs432166 was significantly associated with sIgE for Blomia tropicalis or atleast one of the allergen tested.28076799
46ADCY9rs2601777rs2601777 was significantly associated with sIgE for Blomia tropicalis or atleast one of the allergen tested.28076799
47ADCY9rs6500567rs6500567 was significantly associated with skin prick test for Periplaneta americana or atleast one of the allergen tested. rs6500567 was significantly associated with sTgE for Dermatophagoides pteronyssinus.28076799
48ADCY9rs4785953rs4785953 was significantly associated with sIgE for Blomia tropicalis and Dermatophagoides pteronyssinus.28076799
49ADCY9rs2444217rs2444217 was significantly associated with sIgE for Blomia tropicalis. rs2444217 was significantly associated with skin prick test for Dermatophagoides pteronyssinus or atleast one of the allergen tested.28076799
50ADCY9rs8045426rs8045426 was significantly associated with sIgE for Blomia tropicalis. rs8045426 was significantly associated with unstimulated IL5 and IL13 production.28076799
51ADCY9rs7196832rs7196832 was significantly associated with skin prick test for cat epithelium. rs7196832 was significantly associated with unstimulated IL5 production.28076799
52ADCY9rs2108987rs2108987 was significantly associated with skin prick test for dog epithelium and Blatella germanica. rs2108987 was significantly associated with unstimulated IL5 production.28076799
53ADCY9rs2239313rs2239313 was significantly associated with skin prick test for Periplaneta americana, Blomia tropicalis, Dermatophagoides pteronyssinus, dog epithelium or atleast one of the allergen tested.28076799
54ADCY9rs4785951rs4785951 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus, dog epithelium or atleast one of the allergen tested.28076799
55ADCY9rs13337675rs13337675 was significantly associated with skin prick test for Blatella germanica.28076799
56ADCY9rs2601798rs2601798 was significantly associated with skin prick test for Blatella germanica. rs2601798 was significantly associated with unstimulated IL5 production.28076799
57ADCY9rs61042195rs61042195 was significantly associated with skin prick test for Blomia tropicalis and Dermatophagoides pteronyssinus.28076799
58ADCY9rs2601807rs2601807 was significantly associated with skin prick test for Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested.28076799
59ADCY9rs2531995rs2531995 was significantly associated with skin prick test for Periplaneta americana, Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested. rs2531995 was significantly associated with unstimulated IL13 production.28076799
60ADCY9rs409963rs409963 was significantly associated with skin prick test for Periplaneta americana or atleast one of the allergen tested.28076799
61ADCY9rs2532019rs2532019 was significantly associated with skin prick test for Periplaneta americana and Dermatophagoides pteronyssinus.28076799
62ADCY9rs9922384rs9922384 was significantly associated with skin prick test for Periplaneta americana and Dermatophagoides pteronyssinus.28076799
63ADCY9rs2058166rs2058166 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus or atleast one of the allergen tested.28076799
64ADCY9rs2601831rs2601831 was significantly associated with skin prick test for Dermatophagoides pteronyssinus or atleast one of the allergen tested.28076799
65ADCY9rs79964474rs79964474 was significantly associated with skin prick test for Dermatophagoides pteronyssinus or atleast one of the allergen tested.28076799
66ADCY9rs73490519rs73490519 was significantly associated with skin prick test for Dermatophagoides pteronyssinus or atleast one of the allergen tested.28076799
67ADCY9rs1045476rs1045476 was significantly associated with skin prick test for Dermatophagoides pteronyssinus and unstimulated IL13 production.28076799