RESULT OF MUTATION
Total records: 1 Records
 
Record No:1
ACCESS NO | 300674 |
GENE_NAME | TGFB1 |
dbSNP_ID | rs1800470 |
CHANGES | C/G/T (REV) |
ANCESTRAL_ALLELES | C |
FUNCTIONAL_CONSEQUENCES | Missense Variant |
DISEASE | Allergic Asthma and Helminth Infection (In Children) |
POPULATION | African Admixed population |
PMID | 28284979 |
COMMENTS | An association between rs1800470 (C allele) and atopic wheezing and markers of allergy was noted. A positive association was observed between the haplotype ACCA and Trichuris trichiura infection and Ascaris lumbricoides infection. This haplotype was also associated with increased IL10 production. Individuals with TGFB1 polymorphisms have an increased susceptibility to helminth infections and a lower risk of developing allergy. |