1173 predicted and 1546 experimentally verified small molecules from publicly available literatures and databases for three well-known target PPIs (Mdm2/P53, Bcl2/Bak and c-Myc/Max) had been curated a database, named as PPIMdb, a database of small molecules that inhibit orthosteric Protein-Protein Interactions (PPIs).

The database has 2719 small molecules PPIMs with 25 different attributes for three target PPIs namely, Mdm2/P53, Bcl2/Bak and c-Myc/Max. The attribute named, 'DB_ACCESS_NUMBER' is primary key of the database. There are two important tools have been included in the database, such as PPIMpred (Prediction of novel PPIMs) and PPIM-IC50Pred (IC50 value prediction of PPIMs). The block diagram represents overall architecture of the database.

Figure. Block-diagram of PPIM-db (Protein-Protein Interaction Modulators Database)

Information regarding attributes of PPIM-db

PPIM_SVM_SCORE (Protein-Protein Interaction Modulator SVM score)

IC50_PREDICTION_VALUE (Log ₁₀ (IC50) values)