PPIMdb is a database of small molecules that inhibit orthosteric Protein-Protein Interactions (PPIs). These small molecules are very useful in designing drugs for cancer. This database contains both experimentally verified and predicted compounds for three popular PPI complexes Such as, Mdm2/P53, Bcl2/Bak and c-Myc/Max. There are two tools have been included in the database, such as PPIMpred (Prediction of novel PPIMs) and PPIM-IC50Pred (IC50 value prediction of PPIMs).