Browse Result of Experimentally Verified Mdm2/P53 (622)

Record No:1

DB_ACCESS_NUMBER	PPIM0001
CID	656933
CHEMBL_ID	CHEMBL361103
NSC_ID
PDB_CODE	1T4E
Molecular Weight (g/mol)	581.18
XLogP3-AA	5.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Complexity	725
Topological Polar Surface Area (A^2)	86.7
Heavy Atom Count	32
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	200
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes (Improving the production of influenza viruses and vaccine seeds and also an inhibitor of the in
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	17427181
Protein-Protein Interaction Modulator SVM score	1.1736571
Predicted Log 10(IC50) values	2.6896732
2D Structure

Record No:2

DB_ACCESS_NUMBER	PPIM0002
CID	637760
CHEMBL_ID	CHEMBL7976
NSC_ID	NSC4523
PDB_CODE
Molecular Weight (g/mol)	208.26
XLogP3-AA	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	3
Complexity	242
Topological Polar Surface Area (A^2)	17.1
Heavy Atom Count	16
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	1700
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes (Antibacterial, antifungal, antitumor and anti-inflammatory properties)
Off Targets	Alkaline phosphatase; Abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) ; Guanine nuc
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	17427181
Protein-Protein Interaction Modulator SVM score	-0.47087886
Predicted Log 10(IC50) values	4.557014
2D Structure

Record No:3

DB_ACCESS_NUMBER	PPIM0003
CID	46700806
CHEMBL_ID	CHEMBL1094278
NSC_ID	NSC749793
PDB_CODE
Molecular Weight (g/mol)	225.38
XLogP3-AA	1.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Complexity	128
Topological Polar Surface Area (A^2)	106
Heavy Atom Count	12
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	300
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	ALDH1-BCA2
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20222671
Protein-Protein Interaction Modulator SVM score	0.99881215
Predicted Log 10(IC50) values	2.7597162
2D Structure

Record No:4

DB_ACCESS_NUMBER	PPIM0004
CID	46700805
CHEMBL_ID	CHEMBL1097571
NSC_ID	NSC749792
PDB_CODE
Molecular Weight (g/mol)	265.49
XLogP3-AA	4.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	9
Complexity	158
Topological Polar Surface Area (A^2)	85.9
Heavy Atom Count	15
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	230
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	ALDH1A1-BCA2
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20222671
Protein-Protein Interaction Modulator SVM score	1.0003715
Predicted Log 10(IC50) values	3.6835456
2D Structure

Record No:5

DB_ACCESS_NUMBER	PPIM0005
CID	7188
CHEMBL_ID	CHEMBL121516
NSC_ID	NSC527035
PDB_CODE
Molecular Weight (g/mol)	320.54
XLogP3-AA	3.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Complexity	267
Topological Polar Surface Area (A^2)	121
Heavy Atom Count	18
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	30
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes (used as a standardized Chemical Allergen and The physiologic effect of dipentamethylenethiuram
Off Targets	Androgen receptor (AR); estrogen receptor alpha (ER-alpha);peroxisome proliferator-activated recept
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20222671
Protein-Protein Interaction Modulator SVM score	0.99960096
Predicted Log 10(IC50) values	3.378071
2D Structure

Record No:6

DB_ACCESS_NUMBER	PPIM0006
CID	44825260
CHEMBL_ID	CHEMBL1233798
NSC_ID
PDB_CODE	3LBK
Molecular Weight (g/mol)	462.33
XLogP3-AA	6.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Complexity	653
Topological Polar Surface Area (A^2)	70.9
Heavy Atom Count	32
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes (Substituted Heterocycles as Therapeutic agents for treating cancer)
Off Targets	Mdmx
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	22789708
Protein-Protein Interaction Modulator SVM score	1.0082886
Predicted Log 10(IC50) values	2.8872132
2D Structure

Record No:7

DB_ACCESS_NUMBER	PPIM0007
CID	49867311
CHEMBL_ID	CHEMBL1234332
NSC_ID
PDB_CODE	3LBL
Molecular Weight (g/mol)	577.52
XLogP3-AA	4.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Complexity	900
Topological Polar Surface Area (A^2)	82.7
Heavy Atom Count	39
Defined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	190
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	22789708
Protein-Protein Interaction Modulator SVM score	1.303682
Predicted Log 10(IC50) values	1.9521569
2D Structure

Record No:8

DB_ACCESS_NUMBER	PPIM0008
CID	24969086
CHEMBL_ID	CHEMBL1236726
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	629.63
XLogP3-AA	6.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	10
Complexity	927
Topological Polar Surface Area (A^2)	60.4
Heavy Atom Count	44
Defined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	190
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	Mdmx
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	24751445
Protein-Protein Interaction Modulator SVM score	-0.33884582
Predicted Log 10(IC50) values	2.7050095
2D Structure

Record No:9

DB_ACCESS_NUMBER	PPIM0009
CID	52941444
CHEMBL_ID	CHEMBL1256047
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	871.08
XLogP3-AA	7
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	21
Complexity	1480
Topological Polar Surface Area (A^2)	216
Heavy Atom Count	63
Defined Atom Stereocenter Count	6
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	0.99901666
Predicted Log 10(IC50) values	2.9193385
2D Structure

Record No:10

DB_ACCESS_NUMBER	PPIM0010
CID	52946294
CHEMBL_ID	CHEMBL1256056
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	711.30
XLogP3-AA
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	16
Complexity	1130
Topological Polar Surface Area (A^2)	197
Heavy Atom Count	50
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Experimentally verified IC50 values (nM)	463000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	1.0385888
Predicted Log 10(IC50) values	1.542992
2D Structure

Record No:11

DB_ACCESS_NUMBER	PPIM0011
CID	52941446
CHEMBL_ID	CHEMBL1256057
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	708.86
XLogP3-AA	3.8
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	17
Complexity	1180
Topological Polar Surface Area (A^2)	197
Heavy Atom Count	52
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	0.99902717
Predicted Log 10(IC50) values	0.86338563
2D Structure

Record No:12

DB_ACCESS_NUMBER	PPIM0012
CID	52943866
CHEMBL_ID	CHEMBL1256058
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	666.82
XLogP3-AA	3.1
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	17
Complexity	1100
Topological Polar Surface Area (A^2)	197
Heavy Atom Count	49
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	0.99959732
Predicted Log 10(IC50) values	1.1611493
2D Structure

Record No:13

DB_ACCESS_NUMBER	PPIM0013
CID	52949944
CHEMBL_ID	CHEMBL1256059
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	680.85
XLogP3-AA	3.5
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	17
Complexity	1140
Topological Polar Surface Area (A^2)	197
Heavy Atom Count	50
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	1.168493
Predicted Log 10(IC50) values	1.2017006
2D Structure

Record No:14

DB_ACCESS_NUMBER	PPIM0014
CID	52948744
CHEMBL_ID	CHEMBL1256060
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	714.87
XLogP3-AA	3.7
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	18
Complexity	1190
Topological Polar Surface Area (A^2)	197
Heavy Atom Count	53
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	1.2611294
Predicted Log 10(IC50) values	0.72362206
2D Structure

Record No:15

DB_ACCESS_NUMBER	PPIM0015
CID	52941447
CHEMBL_ID	CHEMBL1256061
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	696.85
XLogP3-AA	3.8
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	19
Complexity	1140
Topological Polar Surface Area (A^2)	206
Heavy Atom Count	51
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	2.1323087
Predicted Log 10(IC50) values	1.6786999
2D Structure

Record No:16

DB_ACCESS_NUMBER	PPIM0016
CID	52949945
CHEMBL_ID	CHEMBL1256062
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	696.85
XLogP3-AA	3.5
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	18
Complexity	1160
Topological Polar Surface Area (A^2)	206
Heavy Atom Count	51
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	307000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	1.7629838
Predicted Log 10(IC50) values	1.4924898
2D Structure

Record No:17

DB_ACCESS_NUMBER	PPIM0017
CID	52943867
CHEMBL_ID	CHEMBL1256064
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	662.83
XLogP3-AA	3
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	17
Complexity	1110
Topological Polar Surface Area (A^2)	206
Heavy Atom Count	48
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	339000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	1.4760306
Predicted Log 10(IC50) values	1.639065
2D Structure

Record No:18

DB_ACCESS_NUMBER	PPIM0018
CID	52945083
CHEMBL_ID	CHEMBL1256067
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	662.83
XLogP3-AA	3.4
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	18
Complexity	1080
Topological Polar Surface Area (A^2)	206
Heavy Atom Count	48
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	300000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	0.71963455
Predicted Log 10(IC50) values	1.5173317
2D Structure

Record No:19

DB_ACCESS_NUMBER	PPIM0019
CID	52949947
CHEMBL_ID	CHEMBL1256068
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	632.81
XLogP3-AA	2.7
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	16
Complexity	1050
Topological Polar Surface Area (A^2)	197
Heavy Atom Count	46
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	-2.3381888
Predicted Log 10(IC50) values	1.4147921
2D Structure

Record No:20

DB_ACCESS_NUMBER	PPIM0020
CID	52949948
CHEMBL_ID	CHEMBL1256069
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	646.83
XLogP3-AA	3
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	16
Complexity	1090
Topological Polar Surface Area (A^2)	197
Heavy Atom Count	47
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	0.20393294
Predicted Log 10(IC50) values	1.2490582
2D Structure

Record No:21

DB_ACCESS_NUMBER	PPIM0021
CID	52948745
CHEMBL_ID	CHEMBL1256070
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	680.85
XLogP3-AA	3.2
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	17
Complexity	1140
Topological Polar Surface Area (A^2)	197
Heavy Atom Count	50
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	1.1857904
Predicted Log 10(IC50) values	1.2012696
2D Structure

Record No:22

DB_ACCESS_NUMBER	PPIM0022
CID	52946296
CHEMBL_ID	CHEMBL1256071
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	730.87
XLogP3-AA	4
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	19
Complexity	1210
Topological Polar Surface Area (A^2)	206
Heavy Atom Count	54
Defined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	No
Off Targets	MDMX
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	2.0295712
Predicted Log 10(IC50) values	0.72916498
2D Structure

Record No:23

DB_ACCESS_NUMBER	PPIM0023
CID	52945084
CHEMBL_ID	CHEMBL1256073
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	757.92
XLogP3-AA	6
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	17
Complexity	1240
Topological Polar Surface Area (A^2)	186
Heavy Atom Count	55
Defined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	20638853
Protein-Protein Interaction Modulator SVM score	0.99474115
Predicted Log 10(IC50) values	-0.14952915
2D Structure

Record No:24

DB_ACCESS_NUMBER	PPIM0024
CID	179269
CHEMBL_ID	CHEMBL151233
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	339.51
XLogP3-AA	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Complexity	260
Topological Polar Surface Area (A^2)	171
Heavy Atom Count	18
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	18977148
Protein-Protein Interaction Modulator SVM score	2.7707152
Predicted Log 10(IC50) values	3.0615533
2D Structure

Record No:25

DB_ACCESS_NUMBER	PPIM0025
CID	51349561
CHEMBL_ID	CHEMBL1688136
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	301.77
XLogP3-AA	3.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Complexity	394
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	21
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	69000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.072080262
Predicted Log 10(IC50) values	3.8605631
2D Structure

Record No:26

DB_ACCESS_NUMBER	PPIM0026
CID	3608080
CHEMBL_ID	CHEMBL1688137
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	349.81
XLogP3-AA	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Complexity	484
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	25
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	74000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.2089365
Predicted Log 10(IC50) values	3.2092999
2D Structure

Record No:27

DB_ACCESS_NUMBER	PPIM0027
CID	51349562
CHEMBL_ID	CHEMBL1688138
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	367.80
XLogP3-AA	4.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Complexity	516
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	20000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.765736
Predicted Log 10(IC50) values	3.1906638
2D Structure

Record No:28

DB_ACCESS_NUMBER	PPIM0028
CID	51349563
CHEMBL_ID	CHEMBL1688139
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	384.25
XLogP3-AA	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Complexity	514
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	4200
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.8145519
Predicted Log 10(IC50) values	2.9465144
2D Structure

Record No:29

DB_ACCESS_NUMBER	PPIM0029
CID	51349698
CHEMBL_ID	CHEMBL1688140
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	428.71
XLogP3-AA	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Complexity	516
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	4500
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.0001225
Predicted Log 10(IC50) values	3.2369932
2D Structure

Record No:30

DB_ACCESS_NUMBER	PPIM0030
CID	51349699
CHEMBL_ID	CHEMBL1688141
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	475.71
XLogP3-AA	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Complexity	516
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	20000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	-0.32336503
Predicted Log 10(IC50) values	4.5443939
2D Structure

Record No:31

DB_ACCESS_NUMBER	PPIM0031
CID	51349700
CHEMBL_ID	CHEMBL1688142
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	363.84
XLogP3-AA	4.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Complexity	510
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	15000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.6161952
Predicted Log 10(IC50) values	3.1844531
2D Structure

Record No:32

DB_ACCESS_NUMBER	PPIM0032
CID	51349701
CHEMBL_ID	CHEMBL1688143
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	374.82
XLogP3-AA	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Complexity	601
Topological Polar Surface Area (A^2)	64.3
Heavy Atom Count	27
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	6000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.7706334
Predicted Log 10(IC50) values	4.5535573
2D Structure

Record No:33

DB_ACCESS_NUMBER	PPIM0033
CID	51349702
CHEMBL_ID	CHEMBL1688144
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	360.36
XLogP3-AA	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Complexity	563
Topological Polar Surface Area (A^2)	86.4
Heavy Atom Count	27
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	87000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.48705926
Predicted Log 10(IC50) values	4.2605426
2D Structure

Record No:34

DB_ACCESS_NUMBER	PPIM0034
CID	51349703
CHEMBL_ID	CHEMBL1688145
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	378.35
XLogP3-AA	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Complexity	596
Topological Polar Surface Area (A^2)	86.4
Heavy Atom Count	28
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	9460
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.0918278
Predicted Log 10(IC50) values	4.2999957
2D Structure

Record No:35

DB_ACCESS_NUMBER	PPIM0035
CID	51349704
CHEMBL_ID	CHEMBL1688146
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	394.81
XLogP3-AA	3.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Complexity	596
Topological Polar Surface Area (A^2)	86.4
Heavy Atom Count	28
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	2400
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.0000573
Predicted Log 10(IC50) values	3.6112689
2D Structure

Record No:36

DB_ACCESS_NUMBER	PPIM0036
CID	51349834
CHEMBL_ID	CHEMBL1688147
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	439.26
XLogP3-AA	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Complexity	596
Topological Polar Surface Area (A^2)	86.4
Heavy Atom Count	28
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	3100
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.58934417
Predicted Log 10(IC50) values	2.6519768
2D Structure

Record No:37

DB_ACCESS_NUMBER	PPIM0037
CID	51349835
CHEMBL_ID	CHEMBL1688148
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	394.81
XLogP3-AA	3.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Complexity	604
Topological Polar Surface Area (A^2)	86.4
Heavy Atom Count	28
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	54000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.146095
Predicted Log 10(IC50) values	3.8087097
2D Structure

Record No:38

DB_ACCESS_NUMBER	PPIM0038
CID	51349836
CHEMBL_ID	CHEMBL1688149
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	363.84
XLogP3-AA	4.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Complexity	498
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	7200
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes(pharmaceutical substance for the treatment of cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.4266367
Predicted Log 10(IC50) values	3.0852945
2D Structure

Record No:39

DB_ACCESS_NUMBER	PPIM0039
CID	51349837
CHEMBL_ID	CHEMBL1688150
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	408.83
XLogP3-AA	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Complexity	610
Topological Polar Surface Area (A^2)	86.4
Heavy Atom Count	29
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	6200
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer & Also treatment for diabetes).
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.017168
Predicted Log 10(IC50) values	3.491536
2D Structure

Record No:40

DB_ACCESS_NUMBER	PPIM0040
CID	51349838
CHEMBL_ID	CHEMBL1688151
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	378.85
XLogP3-AA	3.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Complexity	528
Topological Polar Surface Area (A^2)	66.6
Heavy Atom Count	27
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	6200
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.79499265
Predicted Log 10(IC50) values	2.5792265
2D Structure

Record No:41

DB_ACCESS_NUMBER	PPIM0041
CID	51349839
CHEMBL_ID	CHEMBL1688152
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	399.87
XLogP3-AA	5.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Complexity	604
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	29
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	47000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.000146
Predicted Log 10(IC50) values	3.8829658
2D Structure

Record No:42

DB_ACCESS_NUMBER	PPIM0042
CID	51349840
CHEMBL_ID	CHEMBL1688153
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	428.71
XLogP3-AA	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Complexity	524
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	100000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.1903918
Predicted Log 10(IC50) values	3.1827272
2D Structure

Record No:43

DB_ACCESS_NUMBER	PPIM0043
CID	51349971
CHEMBL_ID	CHEMBL1688154
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	395.90
XLogP3-AA	4.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Complexity	530
Topological Polar Surface Area (A^2)	65.8
Heavy Atom Count	27
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	20000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.60766401
Predicted Log 10(IC50) values	2.3290213
2D Structure

Record No:44

DB_ACCESS_NUMBER	PPIM0044
CID	51349972
CHEMBL_ID	CHEMBL1688155
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	411.9
XLogP3-AA	3.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Complexity	601
Topological Polar Surface Area (A^2)	76.8
Heavy Atom Count	28
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	100000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.4308489
Predicted Log 10(IC50) values	3.3648552
2D Structure

Record No:45

DB_ACCESS_NUMBER	PPIM0045
CID	51349973
CHEMBL_ID	CHEMBL1688156
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	427.89
XLogP3-AA	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Complexity	707
Topological Polar Surface Area (A^2)	83.1
Heavy Atom Count	29
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	100000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.6776929
Predicted Log 10(IC50) values	5.2910218
2D Structure

Record No:46

DB_ACCESS_NUMBER	PPIM0046
CID	51349974
CHEMBL_ID	CHEMBL1688157
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	428.88
XLogP3-AA	2.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Complexity	711
Topological Polar Surface Area (A^2)	109
Heavy Atom Count	29
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	100000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.79155448
Predicted Log 10(IC50) values	4.6884195
2D Structure

Record No:47

DB_ACCESS_NUMBER	PPIM0047
CID	51349975
CHEMBL_ID	CHEMBL1688158
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	417.81
XLogP3-AA	4.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Complexity	599
Topological Polar Surface Area (A^2)	40.5
Heavy Atom Count	29
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	100000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.0508984
Predicted Log 10(IC50) values	3.5036294
2D Structure

Record No:48

DB_ACCESS_NUMBER	PPIM0048
CID	51349976
CHEMBL_ID	CHEMBL1688159
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	407.85
XLogP3-AA	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Complexity	612
Topological Polar Surface Area (A^2)	66.8
Heavy Atom Count	29
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	11000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.5319595
Predicted Log 10(IC50) values	3.8897193
2D Structure

Record No:49

DB_ACCESS_NUMBER	PPIM0049
CID	51350114
CHEMBL_ID	CHEMBL1688160
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	393.82
XLogP3-AA	3.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Complexity	597
Topological Polar Surface Area (A^2)	77.8
Heavy Atom Count	28
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	100000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.4019136
Predicted Log 10(IC50) values	3.7618635
2D Structure

Record No:50

DB_ACCESS_NUMBER	PPIM0050
CID	51350115
CHEMBL_ID	CHEMBL1688161
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	391.85
XLogP3-AA	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Complexity	595
Topological Polar Surface Area (A^2)	57.6
Heavy Atom Count	28
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	88000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.705789
Predicted Log 10(IC50) values	3.8675495
2D Structure

Record No:51

DB_ACCESS_NUMBER	PPIM0051
CID	51350116
CHEMBL_ID	CHEMBL1688162
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	453.92
XLogP3-AA	5.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Complexity	706
Topological Polar Surface Area (A^2)	57.6
Heavy Atom Count	33
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	20000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.1562482
Predicted Log 10(IC50) values	4.6089521
2D Structure

Record No:52

DB_ACCESS_NUMBER	PPIM0052
CID	51350117
CHEMBL_ID	CHEMBL1688163
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	350.80
XLogP3-AA	2.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Complexity	488
Topological Polar Surface Area (A^2)	53.4
Heavy Atom Count	25
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	20000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.3450629
Predicted Log 10(IC50) values	2.8051448
2D Structure

Record No:53

DB_ACCESS_NUMBER	PPIM0053
CID	51350118
CHEMBL_ID	CHEMBL1688164
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	350.80
XLogP3-AA	2.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Complexity	494
Topological Polar Surface Area (A^2)	53.4
Heavy Atom Count	25
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	200000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.4131181
Predicted Log 10(IC50) values	2.846895
2D Structure

Record No:54

DB_ACCESS_NUMBER	PPIM0054
CID	51350119
CHEMBL_ID	CHEMBL1688165
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	350.80
XLogP3-AA	3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Complexity	494
Topological Polar Surface Area (A^2)	53.4
Heavy Atom Count	25
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	200000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.4044794
Predicted Log 10(IC50) values	2.8462635
2D Structure

Record No:55

DB_ACCESS_NUMBER	PPIM0055
CID	51350120
CHEMBL_ID	CHEMBL1688166
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	366.80
XLogP3-AA	1.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Complexity	517
Topological Polar Surface Area (A^2)	66
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	200000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.019465
Predicted Log 10(IC50) values	2.6555131
2D Structure

Record No:56

DB_ACCESS_NUMBER	PPIM0056
CID	51350252
CHEMBL_ID	CHEMBL1688167
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	366.80
XLogP3-AA	1.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Complexity	525
Topological Polar Surface Area (A^2)	66
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	200000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.1674691
Predicted Log 10(IC50) values	2.8552917
2D Structure

Record No:57

DB_ACCESS_NUMBER	PPIM0057
CID	51350253
CHEMBL_ID	CHEMBL1688168
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	366.80
XLogP3-AA	2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Complexity	525
Topological Polar Surface Area (A^2)	66
Heavy Atom Count	26
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	200000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.1583505
Predicted Log 10(IC50) values	2.8538119
2D Structure

Record No:58

DB_ACCESS_NUMBER	PPIM0058
CID	53318463
CHEMBL_ID	CHEMBL1688169
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	369.43
XLogP3-AA	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Complexity	536
Topological Polar Surface Area (A^2)	49.8
Heavy Atom Count	27
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	20000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.7031127
Predicted Log 10(IC50) values	3.2556787
2D Structure

Record No:59

DB_ACCESS_NUMBER	PPIM0059
CID	11502965
CHEMBL_ID	CHEMBL1688170
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	433.93
XLogP3-AA	4.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Complexity	630
Topological Polar Surface Area (A^2)	49.8
Heavy Atom Count	31
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	3000
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.0649762
Predicted Log 10(IC50) values	4.1474197
2D Structure

Record No:60

DB_ACCESS_NUMBER	PPIM0060
CID	11591070
CHEMBL_ID	CHEMBL1688251
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	478.92
XLogP3-AA	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Complexity	746
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	34
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	700
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.2482423
Predicted Log 10(IC50) values	4.2176187
2D Structure

Record No:61

DB_ACCESS_NUMBER	PPIM0061
CID	53318519
CHEMBL_ID	CHEMBL1688252
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	478.92
XLogP3-AA	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Complexity	746
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	34
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	400
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.2644696
Predicted Log 10(IC50) values	4.0376853
2D Structure

Record No:62

DB_ACCESS_NUMBER	PPIM0062
CID	53322938
CHEMBL_ID	CHEMBL1688253
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	458.94
XLogP3-AA	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Complexity	752
Topological Polar Surface Area (A^2)	73.6
Heavy Atom Count	33
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	2300
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.2674509
Predicted Log 10(IC50) values	3.9144382
2D Structure

Record No:63

DB_ACCESS_NUMBER	PPIM0063
CID	44595458
CHEMBL_ID	CHEMBL1688254
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	431.91
XLogP3-AA	4.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Complexity	670
Topological Polar Surface Area (A^2)	49.8
Heavy Atom Count	31
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	2300
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.0510125
Predicted Log 10(IC50) values	5.2777624
2D Structure

Record No:64

DB_ACCESS_NUMBER	PPIM0064
CID	44595318
CHEMBL_ID	CHEMBL1688255
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	466.35
XLogP3-AA	5.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Complexity	701
Topological Polar Surface Area (A^2)	49.8
Heavy Atom Count	32
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	1500
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.2524758
Predicted Log 10(IC50) values	3.8997111
2D Structure

Record No:65

DB_ACCESS_NUMBER	PPIM0065
CID	44595320
CHEMBL_ID	CHEMBL1688256
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	445.94
XLogP3-AA	4.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Complexity	697
Topological Polar Surface Area (A^2)	49.8
Heavy Atom Count	32
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	1400
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.1444925
Predicted Log 10(IC50) values	4.8870386
2D Structure

Record No:66

DB_ACCESS_NUMBER	PPIM0066
CID	44594120
CHEMBL_ID	CHEMBL1688257
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	476.91
XLogP3-AA	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Complexity	787
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	34
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	1400
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.3820606
Predicted Log 10(IC50) values	3.2774142
2D Structure

Record No:67

DB_ACCESS_NUMBER	PPIM0067
CID	44595462
CHEMBL_ID	CHEMBL1688258
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	464.90
XLogP3-AA	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	712
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	33
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	402
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.81734576
Predicted Log 10(IC50) values	4.0867566
2D Structure

Record No:68

DB_ACCESS_NUMBER	PPIM0068
CID	25227971
CHEMBL_ID	CHEMBL1688259
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	452.89
XLogP3-AA	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	657
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	32
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	450
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.45907176
Predicted Log 10(IC50) values	3.0597002
2D Structure

Record No:69

DB_ACCESS_NUMBER	PPIM0069
CID	25227848
CHEMBL_ID	CHEMBL1688260
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	466.91
XLogP3-AA	4.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Complexity	672
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	33
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	360
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	no
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.25061559
Predicted Log 10(IC50) values	2.6671463
2D Structure

Record No:70

DB_ACCESS_NUMBER	PPIM0070
CID	44595461
CHEMBL_ID	CHEMBL1688261
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	446.93
XLogP3-AA	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Complexity	678
Topological Polar Surface Area (A^2)	73.6
Heavy Atom Count	32
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	3500
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.99950948
Predicted Log 10(IC50) values	4.5260392
2D Structure

Record No:71

DB_ACCESS_NUMBER	PPIM0071
CID	51350512
CHEMBL_ID	CHEMBL1688262
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	470.39
XLogP3-AA	5.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	8
Complexity	618
Topological Polar Surface Area (A^2)	49.8
Heavy Atom Count	32
Defined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	869
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.849389
Predicted Log 10(IC50) values	2.9020718
2D Structure

Record No:72

DB_ACCESS_NUMBER	PPIM0072
CID	44595460
CHEMBL_ID	CHEMBL1688263
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	470.39
XLogP3-AA	5.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	8
Complexity	618
Topological Polar Surface Area (A^2)	49.8
Heavy Atom Count	32
Defined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	2500
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.849389
Predicted Log 10(IC50) values	2.9020718
2D Structure

Record No:73

DB_ACCESS_NUMBER	PPIM0073
CID	44595459
CHEMBL_ID	CHEMBL1688264
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	480.94
XLogP3-AA	4.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	9
Complexity	687
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	34
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	3200
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.015384035
Predicted Log 10(IC50) values	2.3667347
2D Structure

Record No:74

DB_ACCESS_NUMBER	PPIM0074
CID	51350513
CHEMBL_ID	CHEMBL1688265
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	497.34
XLogP3-AA	4.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	657
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	32
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	1400
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.10756239
Predicted Log 10(IC50) values	0.40285933
2D Structure

Record No:75

DB_ACCESS_NUMBER	PPIM0075
CID	51350514
CHEMBL_ID	CHEMBL1688266
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	511.37
XLogP3-AA	4.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Complexity	672
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	33
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	570
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	-0.16148092
Predicted Log 10(IC50) values	0.0839374
2D Structure

Record No:76

DB_ACCESS_NUMBER	PPIM0076
CID	51350515
CHEMBL_ID	CHEMBL1688267
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	514.96
XLogP3-AA	5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	784
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	37
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	980
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.94233277
Predicted Log 10(IC50) values	3.9721113
2D Structure

Record No:77

DB_ACCESS_NUMBER	PPIM0077
CID	51350516
CHEMBL_ID	CHEMBL1688268
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	521.01
XLogP3-AA	5.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	784
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	37
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	580
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.85403446
Predicted Log 10(IC50) values	4.0742075
2D Structure

Record No:78

DB_ACCESS_NUMBER	PPIM0078
CID	51350650
CHEMBL_ID	CHEMBL1688269
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	514.96
XLogP3-AA	5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	792
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	37
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	730
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.99880067
Predicted Log 10(IC50) values	3.7271587
2D Structure

Record No:79

DB_ACCESS_NUMBER	PPIM0079
CID	44595463
CHEMBL_ID	CHEMBL1688270
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	521.01
XLogP3-AA	5.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Complexity	782
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	37
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	380
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.9189064
Predicted Log 10(IC50) values	4.2195115
2D Structure

Record No:80

DB_ACCESS_NUMBER	PPIM0080
CID	44595606
CHEMBL_ID	CHEMBL1688271
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	462.88
XLogP3-AA	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Complexity	773
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	33
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	660
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.4172719
Predicted Log 10(IC50) values	3.6514273
2D Structure

Record No:81

DB_ACCESS_NUMBER	PPIM0081
CID	51350651
CHEMBL_ID	CHEMBL1688272
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	521.01
XLogP3-AA	5.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	792
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	37
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	569
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.95673022
Predicted Log 10(IC50) values	3.6017565
2D Structure

Record No:82

DB_ACCESS_NUMBER	PPIM0082
CID	44595605
CHEMBL_ID	CHEMBL1688273
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	480.94
XLogP3-AA	4.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	727
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	34
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	395
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	0.79759588
Predicted Log 10(IC50) values	3.9755155
2D Structure

Record No:83

DB_ACCESS_NUMBER	PPIM0083
CID	53318520
CHEMBL_ID	CHEMBL1688274
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	478.92
XLogP3-AA	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Complexity	755
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	34
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	225
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.2233814
Predicted Log 10(IC50) values	4.088663
2D Structure

Record No:84

DB_ACCESS_NUMBER	PPIM0084
CID	51350652
CHEMBL_ID	CHEMBL1688275
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	492.95
XLogP3-AA	5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Complexity	753
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	35
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	390
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.1538107
Predicted Log 10(IC50) values	4.2597174
2D Structure

Record No:85

DB_ACCESS_NUMBER	PPIM0085
CID	51350653
CHEMBL_ID	CHEMBL1688276
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	490.94
XLogP3-AA	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Complexity	802
Topological Polar Surface Area (A^2)	95.6
Heavy Atom Count	35
Defined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	306
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.3958792
Predicted Log 10(IC50) values	3.0598491
2D Structure

Record No:86

DB_ACCESS_NUMBER	PPIM0086
CID	51350782
CHEMBL_ID	CHEMBL1688277
NSC_ID
PDB_CODE
Molecular Weight (g/mol)	458.94
XLogP3-AA	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Complexity	761
Topological Polar Surface Area (A^2)	73.6
Heavy Atom Count	33
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Experimentally verified IC50 values (nM)	1800
Target Protein-protein Interaction complex	Mdm2/P53
Clinical Application	Yes( Therapeutic agents for treating cancer)
Off Targets	NA
Protein-Protein Interaction Type	Orthosteric
Protein-Protein Interaction Modulator Type	Experimentally Verified or reviewed
PUBMED_ID	21314128
Protein-Protein Interaction Modulator SVM score	1.0701397
Predicted Log 10(IC50) values	3.8299153
2D Structure

Record No:87